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Pharmacokinetic of cyclosporine microemulsion in pediatric kidney recipients receiving A quadruple immunosuppressive regimen: the value of C2 blood levels
- Publication Year :
- 2005
-
Abstract
- Background. The management of cyclosporine therapy in pediatric kidney-transplant recipients is largely based on single center's experience rather than on a univocal pharmacokinetic approach based on therapeutic drug monitoring. A prospective multicenter trial was designed to address the question whether C2 blood level monitoring of cyclosporine microemulsion therapy is feasible in the pediatric setting. Methods. Sixty-four pediatric kidney-transplant recipients receiving a triple immunosuppressive regimen based on cyclosporine microemulsion had their cyclosporine dose adjusted to the same protocol-defined C2 targets from the time of the transplant until 2 years posttransplant. The interim analyses after 1 year of enrolment is presented in this study. Results. One-year patient and graft survival were 100% and 94.8%, respectively. One-year rejection rate was 15%. C2 management of cyclosporine did not affect graft function: 1-year serum creatinine and glomerular filtration rate were 1.3±1 mg/mL and 71.2±20 mL/min/1.73 m 2 , respectively. C2 was the best single-point predictor of the area under the concentration curve throughout the entire follow-up, with a mean coefficient of correlation of 0.97±0.01. Conclusions. C2 management of cyclosporine microemulsion therapy is effective and safe in pediatric kidney-transplant recipients given a combined immunosuppressive treatment.
- Subjects :
- Adult
Graft Rejection
Male
medicine.medical_specialty
Adolescent
Recombinant Fusion Proteins
Urology
Renal function
Infections
Single Center
Basiliximab
chemistry.chemical_compound
Postoperative Complications
Pharmacokinetics
Multicenter trial
medicine
Humans
Child
Transplantation
Creatinine
medicine.diagnostic_test
business.industry
Antibodies, Monoclonal
Complement C2
Ciclosporin
Kidney Transplantation
Surgery
chemistry
Therapeutic drug monitoring
Cyclosporine
Drug Therapy, Combination
Emulsions
Female
business
Biomarkers
Immunosuppressive Agents
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....80718347cccff471f90e309679559e21