Relapse of Hodgkin's Disease After 14 Years of Complete Remission

A 40 year old male patient with nodular lymphocyte predominance Hodgkin's disease had a nodal relapse of the mixed cellularity subtype 14 years after entering complete remission with total nodal irradiation. This case is unusual because of the very long disease-free interval and also because the histology at relapse changed to the mixed cellularity subtype. A review of the literature of late relapses in Hodgkin's disease is presented, and possible mechanisms involved in their development are discussed. Hodgkin's disease.