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Decreased phospholipid polyunsaturated fatty acid content and superoxide dismutase activity in cardiac muscle of malignant hyperthermia-susceptible swine
- Source :
- Comparative biochemistry and physiology. Part B, Biochemistrymolecular biology. 112(2)
- Publication Year :
- 1995
-
Abstract
- Homogenates of cardiac left ventricle from malignant hyperthermia-susceptible (MHS) pigs produced a circa 72% more pentane than those from malignant hyperthermia-resistant (MHR) animals, indicating enhanced peroxidation of n-6 fatty acids. This is consistent with the observed circa 70% decrease in total phospholipid polyunsaturated fatty acids (PUFA) in MHS compared with MHR tissue, a decrease mainly due to the quantitatively greater loss of n-6 PUFA. Although the percentage loss of n-3 PUFA was greater than that of n-6 PUFA (90% vs 60%), absolute amounts were insufficient to register as ethane production. Three-fold greater phospholipid content of MHS compared with MHR ventricles indicates reduced neutral lipid content probably due to increased catecholamine stimulation. These findings were associated with a small but significant decrease in superoxide dismutase activity in MHS tissues.
- Subjects :
- medicine.medical_specialty
Physiology
Swine
medicine.medical_treatment
Phospholipid
Biochemistry
Antioxidants
Lipid peroxidation
Superoxide dismutase
chemistry.chemical_compound
Selenium
Internal medicine
medicine
Animals
Vitamin E
Molecular Biology
chemistry.chemical_classification
biology
Superoxide Dismutase
Myocardium
Malignant hyperthermia
Cardiac muscle
Lipid metabolism
medicine.disease
Lipids
Endocrinology
medicine.anatomical_structure
chemistry
biology.protein
Fatty Acids, Unsaturated
lipids (amino acids, peptides, and proteins)
Malignant Hyperthermia
Polyunsaturated fatty acid
Subjects
Details
- ISSN :
- 10964959
- Volume :
- 112
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Comparative biochemistry and physiology. Part B, Biochemistrymolecular biology
- Accession number :
- edsair.doi.dedup.....8063d31daf24cd899b5672e985f4db43