Back to Search
Start Over
Clinicopathological study of intraductal carcinoma of the salivary gland, with emphasis on the apocrine type
- Source :
- Virchows Archiv. 477:581-592
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Intraductal carcinoma (IC) is a rare salivary gland tumor with low- to intermediate-grade cytological features. It is further classified into intercalated duct type and apocrine type based on its distinct histologic and immunohistochemical expression. Conventional salivary duct carcinoma (SDC) is an aggressive carcinoma with high-grade features and is usually associated with poor prognosis. In this study, immunohistochemistry and mutation analyses (including HRAS/PIK3CA mutations, RET rearrangement, and human epidermal growth factor receptor 2 [HER2] amplification) of 9 ICs (including 3 pure ICs, 6 ICs with invasive carcinoma) and 24 conventional SDCs were performed and the results were compared. Four intercalated duct-type cases were positive for SOX10 and S100 and negative for AR; five apocrine-type cases showed opposite results. All five apocrine-type cases had cysts with relatively circumscribed tumor borders and morphologically mimicking breast low-grade ductal carcinoma in situ or papillary carcinoma. RET fusion is detected in half of the 4 intercalated duct-type IC but not in the apocrine-type or conventional SDC. HER2 amplification was only observed in conventional SDC. The monoclonal antibody (clone RBT-NRAS) against NRAS Q61R is a sensitive and specific marker used for detecting HRAS Q61R mutation in the salivary gland tumors. The apocrine-type IC had different cytological grades, distinct tumor growth patterns, and no evidence of low- to high-grade transition, suggesting that apocrine-type IC should be distinguished from apocrine SDC with an in situ component.
- Subjects :
- Adult
Male
0301 basic medicine
Pathology
medicine.medical_specialty
DNA Mutational Analysis
Cystadenocarcinoma
Biology
Pathology and Forensic Medicine
Salivary duct carcinoma
Diagnosis, Differential
03 medical and health sciences
0302 clinical medicine
Predictive Value of Tests
Biomarkers, Tumor
medicine
Carcinoma
Humans
Genetic Predisposition to Disease
HRAS
Molecular Biology
In Situ Hybridization, Fluorescence
Aged
Cell Proliferation
Aged, 80 and over
Gene Rearrangement
Salivary gland
Gene Amplification
Apocrine
Intercalated duct
Cell Biology
General Medicine
Middle Aged
Ductal carcinoma
Salivary Gland Neoplasms
medicine.disease
Immunohistochemistry
Carcinoma, Ductal
Phenotype
030104 developmental biology
medicine.anatomical_structure
030220 oncology & carcinogenesis
Mutation
Female
Neoplasm Grading
Subjects
Details
- ISSN :
- 14322307 and 09456317
- Volume :
- 477
- Database :
- OpenAIRE
- Journal :
- Virchows Archiv
- Accession number :
- edsair.doi.dedup.....8049c2e3204c6ecb624470eff6608a50