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Additive Manufacturing of Material Scaffolds for Bone Regeneration: Toward Application in the Clinics
- Source :
- Advanced Functional Materials, Advanced Functional Materials, Wiley, 2021, 31 (5), pp.2006967. ⟨10.1002/adfm.202006967⟩, Advanced Functional Materials, 2021, 31 (5), pp.2006967. ⟨10.1002/adfm.202006967⟩, Adv Funct Mater
- Publication Year :
- 2021
- Publisher :
- HAL CCSD, 2021.
-
Abstract
- Additive manufacturing (AM) allows the fabrication of customized bone scaffolds in terms of shape, pore size, material type and mechanical properties. Combined with the possibility to obtain a precise 3D image of the bone defects using computed tomography or magnetic resonance imaging, it is now possible to manufacture implants for patient-specific bone regeneration. This paper reviews the state-of-the-art of the different materials and AM techniques used for the fabrication of 3D-printed scaffolds in the field of bone tissue engineering. Their advantages and drawbacks are highlighted. For materials, specific criteria, were extracted from a literature study: biomimetism to native bone, mechanical properties, biodegradability, ability to be imaged (implantation and follow-up period), histological performances and sterilization process. AM techniques can be classified in three major categories: extrusion-based, powder-based and liquid-base. Their price, ease of use and space requirement are analyzed. Different combinations of materials/AM techniques appear to be the most relevant depending on the targeted clinical applications (implantation site, presence of mechanical constraints, temporary or permanent implant). Finally, some barriers impeding the translation to human clinics are identified, notably the sterilization process.
- Subjects :
- Pore size
[SDV.IB] Life Sciences [q-bio]/Bioengineering
Materials science
Material type
business.industry
0206 medical engineering
Implantation Site
3D printing
02 engineering and technology
021001 nanoscience & nanotechnology
Condensed Matter Physics
020601 biomedical engineering
Article
Bone tissue engineering
Electronic, Optical and Magnetic Materials
Biomaterials
Tissue engineering
3d image
Electrochemistry
[SDV.IB]Life Sciences [q-bio]/Bioengineering
0210 nano-technology
Bone regeneration
business
ComputingMilieux_MISCELLANEOUS
Biomedical engineering
Subjects
Details
- Language :
- English
- ISSN :
- 1616301X and 16163028
- Database :
- OpenAIRE
- Journal :
- Advanced Functional Materials, Advanced Functional Materials, Wiley, 2021, 31 (5), pp.2006967. ⟨10.1002/adfm.202006967⟩, Advanced Functional Materials, 2021, 31 (5), pp.2006967. ⟨10.1002/adfm.202006967⟩, Adv Funct Mater
- Accession number :
- edsair.doi.dedup.....80460cfbc3aed81110898904fb7ad905