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Phylogenetic and phylogeographic analyses of porcine circovirus type 2 among pig farms in Vietnam
- Source :
- Transboundary and emerging diseases. 61(6)
- Publication Year :
- 2012
-
Abstract
- Summary This study demonstrated the prevalence of Porcine circovirus type 2 (PCV2) among pig farms in Vietnam. Analyses of the genome, capsid protein and phylogeny classified all 30 Vietnamese PCV2 strains as the PCV2b genotype, belonging to the clusters of 1A, 1B, 1C and recombinant forms. Each viral genome was 1767 nucleotides long and shared 96.0–100% nucleotide sequence identity. The amino acid substitutions in the capsid protein of the Vietnamese PCV2 strains were in immunodominant regions, and the majority of strains (24/30) contained a lysine extension at the C-terminus. Bayesian phylogeographic analysis revealed epidemic links of the PCV2 recombinant cluster within and among countries, which supports a circulating recombinant form of PCV2. Further analysis by the Jameson–Wolf antigenic index indicated antigenic alterations at important sites in the capsid protein (sites 131–133) among the recombinant cluster and the other clusters of PCV2b.
- Subjects :
- Circovirus
Genotype
Swine
animal diseases
Genome, Viral
Genome
law.invention
Phylogenetics
law
Animals
Circoviridae Infections
Phylogeny
Genetics
Swine Diseases
General Veterinary
General Immunology and Microbiology
biology
Phylogenetic tree
Base Sequence
Nucleic acid sequence
virus diseases
Bayes Theorem
General Medicine
biology.organism_classification
Virology
Porcine circovirus
Phylogeography
Capsid
Vietnam
Recombinant DNA
Capsid Proteins
Subjects
Details
- ISSN :
- 18651682
- Volume :
- 61
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Transboundary and emerging diseases
- Accession number :
- edsair.doi.dedup.....803192bb279fe3e9ff73dcb109698bba