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Metabolic consequences of obesity and insulin resistance in polycystic ovary syndrome: diagnostic and methodological challenges
- Source :
- Nutrition Research Reviews. 30:97-105
- Publication Year :
- 2017
- Publisher :
- Cambridge University Press (CUP), 2017.
-
Abstract
- Women with polycystic ovary syndrome (PCOS) have a considerable risk of metabolic dysfunction. This review aims to present contemporary knowledge on obesity, insulin resistance and PCOS with emphasis on the diagnostic and methodological challenges encountered in research and clinical practice. Variable diagnostic criteria for PCOS and associated phenotypes are frequently published. Targeted searches were conducted to identify all available data concerning the association of obesity and insulin resistance with PCOS up to September 2016. Articles were considered if they were peer reviewed, in English and included women with PCOS. Obesity is more prevalent in women with PCOS, but studies rarely reported accurate assessments of adiposity, nor split the study population by PCOS phenotypes. Many women with PCOS have insulin resistance, though there is considerable variation reported in part due to not distinguishing subgroups known to have an impact on insulin resistance as well as limited methodology to measure insulin resistance. Inflammatory markers are positively correlated with androgen levels, but detailed interactions need to be identified. Weight management is the primary therapy; specific advice to reduce the glycaemic load of the diet and reduce the intake of pro-inflammatory SFA and advanced glycation endproducts have provided promising results. It is important that women with PCOS are educated about their increased risk of metabolic complications in order to make timely and appropriate lifestyle modifications. Furthermore, well-designed robust studies are needed to evaluate the mechanisms behind the improvements observed with dietary interventions.
- Subjects :
- medicine.medical_specialty
endocrine system diseases
Medicine (miscellaneous)
030209 endocrinology & metabolism
Bioinformatics
03 medical and health sciences
0302 clinical medicine
Insulin resistance
Metabolic Diseases
Patient Education as Topic
Non-alcoholic Fatty Liver Disease
Risk Factors
Internal medicine
Glucose Intolerance
Weight management
medicine
Humans
Obesity
Adiposity
Metabolic Syndrome
030219 obstetrics & reproductive medicine
Nutrition and Dietetics
business.industry
medicine.disease
Polycystic ovary
female genital diseases and pregnancy complications
Advanced Glycation Endproducts
Diet
Phenotype
Endocrinology
Increased risk
Diabetes Mellitus, Type 2
Population study
Female
Insulin Resistance
Hyperandrogenism
business
Polycystic Ovary Syndrome
Subjects
Details
- ISSN :
- 14752700 and 09544224
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Nutrition Research Reviews
- Accession number :
- edsair.doi.dedup.....80217c86a27ed2c66bd18496358d86ca