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Semiconducting Polymer Nanoparticles for Centimeters-Deep Photoacoustic Imaging in the Second Near-Infrared Window
- Source :
- Advanced Materials. 29:1703403
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Thienoisoindigo-based semiconducting polymer with a strong near-infrared absorbance is synthesized and its water-dispersed nanoparticles (TSPNs) are investigated as a contrast agent for photoacoustic (PA) imaging in the second near-infrared (NIR-II) window (1000-1350 nm). The TSPNs generate a strong PA signal in the NIR-II optical window, where background signals from endogenous contrast agents, including blood and lipid, are at the local minima. By embedding a TSPN-containing tube in chicken-breast tissue, an imaging depth of more than 5 cm at 1064 nm excitation is achieved with a contrast-agent concentration as low as 40 µg mL-1 . The TSPNs under the skin or in the tumor are clearly visualized at 1100 and 1300 nm, with negligible interference from the tissue background. TSPN as a PA contrast in the NIR-II window opens new opportunities for biomedical imaging of deep tissues with improved contrast.
- Subjects :
- Materials science
business.industry
Mechanical Engineering
media_common.quotation_subject
Near-infrared spectroscopy
Nanoparticle
02 engineering and technology
010402 general chemistry
021001 nanoscience & nanotechnology
01 natural sciences
Signal
0104 chemical sciences
Absorbance
Optics
Interference (communication)
Mechanics of Materials
Medical imaging
Contrast (vision)
General Materials Science
0210 nano-technology
business
Excitation
media_common
Subjects
Details
- ISSN :
- 09359648
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Advanced Materials
- Accession number :
- edsair.doi.dedup.....801a313fbb73d82653718fa8aedba870