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Distinct Role of Macrophages in Different Tumor Microenvironments
- Source :
- Cancer Research. 66:605-612
- Publication Year :
- 2006
- Publisher :
- American Association for Cancer Research (AACR), 2006.
-
Abstract
- Macrophages are prominent in the stromal compartment of virtually all types of malignancy. These highly versatile cells respond to the presence of stimuli in different parts of tumors with the release of a distinct repertoire of growth factors, cytokines, chemokines, and enzymes that regulate tumor growth, angiogenesis, invasion, and/or metastasis. The distinct microenvironments where tumor-associated macrophages (TAM) act include areas of invasion where TAMs promote cancer cell motility, stromal and perivascular areas where TAMs promote metastasis, and avascular and perinecrotic areas where hypoxic TAMs stimulate angiogenesis. This review will discuss the evidence for differential regulation of TAMs in these microenvironments and provide an overview of current attempts to target or use TAMs for therapeutic purposes. (Cancer Res 2006; 66(2): 605-12)
- Subjects :
- Cancer Research
Stromal cell
Angiogenesis
Tumor-associated macrophage
Biology
Metastasis
stomatognathic system
Cell Movement
Neoplasms
medicine
Humans
Macrophage
Neoplasm Metastasis
skin and connective tissue diseases
Tumor microenvironment
Neovascularization, Pathologic
Macrophages
Cancer
medicine.disease
Oncology
Cancer cell
Immunology
Disease Progression
Cancer research
Immunotherapy
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 15387445 and 00085472
- Volume :
- 66
- Database :
- OpenAIRE
- Journal :
- Cancer Research
- Accession number :
- edsair.doi.dedup.....8014e49a3ad8f3726fc2dcecf45f8860