Supplementary Figures 1 - 4 from A High-Affinity, High-Stability Photoacoustic Agent for Imaging Gastrin-Releasing Peptide Receptor in Prostate Cancer

PDF file - 300KB, Contains information about the dyes tested and characterization of the imaging agents. Figure S1. Dye Selection. The table lists all the dyes tested with their molecular weight, maximum excitation and emission wavelengths, extinction coefficient and quantum yield. Figure S2. AA3G-740 MALDI spectrum. Figure S3. Cell binding studies. A) Binding of AA3G-740 to PC3 cells was blocked by bombesin in a dose dependent manner. B) LNCaP cells showed minimal binding. At high concentration (30pmol) cell fluorescence was of a similar level as the one corresponding to non-specific binding in PC3 cells Figure S4. Blood lifetime. Very low amount of the agent was at 60 minutes post-injection suggesting short blood lifetime.