Eltrombopag‐associated erythromelalgia in idiopathic thrombocytopenic purpura

Erythromelalgia is a recurrent and paroxysmal syndrome characterized by the clinical triad of bilateral redness, heat, and paroxysmal burning pain, mostly localized on the feet. This disorder can be primary, as a consequence of mutations in the genes encoding the voltage gated sodium channels. It can also be secondary to an underlying disease or drugs. Its pathophysiology involves either an abnormal microvascular arteriovenous shunting together with a decreased nutritional blood flow responsible for the pain , and/or a state of increase blood viscosity.