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The complex role of SIRT7 in p53 stabilization: nucleophosmin joins the debate
- Source :
- Molecular & Cellular Oncology, article-version (VoR) Version of Record
- Publication Year :
- 2021
- Publisher :
- Informa UK Limited, 2021.
-
Abstract
- Release of nucleophosmin (NPM) from nucleoli following stress promotes rapid stabilization of the tumor suppressor p53 (TP53, best known as p53). Nucleoplasmic NPM binds to the ubiquitin ligase mouse double minute 2 (MDM2) and prevents MDM2-dependent p53 degradation. We recently demonstrated that sirtuin 7 (SIRT7) activates this pathway by directly deacetylating NPM following ultraviolet irradiation, indicating tumor-suppressive functions of SIRT7.
- Subjects :
- p53
0301 basic medicine
Cancer Research
Nucleolus
SIRT7
law.invention
03 medical and health sciences
0302 clinical medicine
law
Author’s Views
nucleolus
Nucleophosmin
integumentary system
biology
Chemistry
Cell biology
Ubiquitin ligase
030104 developmental biology
ultraviolet irradiation
030220 oncology & carcinogenesis
Sirtuin
Ultraviolet irradiation
biology.protein
Molecular Medicine
Suppressor
Mdm2
nucleophosmin
Article Commentary
Subjects
Details
- ISSN :
- 23723556
- Database :
- OpenAIRE
- Journal :
- Molecular & Cellular Oncology
- Accession number :
- edsair.doi.dedup.....7fd987e6fd4ef8c8bd3dbbfba4d01377