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Diagnosis of Subclinical Keratoconus with a Combined Model of Biomechanical and Topographic Parameters
- Source :
- riUAL. Repositorio Institucional de la Universidad de Almería, Universidad de Almería, Journal of Clinical Medicine, Volume 10, Issue 13, Journal of Clinical Medicine, Vol 10, Iss 2746, p 2746 (2021)
- Publication Year :
- 2021
-
Abstract
- This study sought to develop a diagnostic model with aberrometry and biomechanical variables for subclinical keratoconus. The design was a cross-sectional study. The topographic data were obtained with a rotating Scheimpflug camera (Pentacam HR), and biomechanical data were obtained with Corvis ST. The study included 81 eyes distributed in 61 healthy corneas and 20 subclinical keratoconus (SCKC), defined as eyes with suspicious topographic findings, normal slit-lamp examination, and a manifestation of keratoconus. Analyses of the topographic and biomechanical data were performed, and a classifying model of SCKC was elaborated. The model for the diagnosis of SCKC includes posterior coma to 90°, Ambrósio’s Relational Thickness in the horizontal profile (ARTh), and velocity when the air pulse is off (A2 velocity). The sensitivity was 89.5%, specificity 96.7%, accuracy 94.9%, and precision 89.5%. The area under the curve (AUC) of the receiver operating characteristic (ROC) curve for the model was 0.951. Diagnosis of subclinical keratoconus depends on the aberrometry variable posterior coma to 90° and the biomechanical variables A2 velocity and ARTh.
- Subjects :
- medicine.medical_specialty
Keratoconus
genetic structures
Corvis ST
Scheimpflug principle
Coma (optics)
Article
biomechanics
03 medical and health sciences
0302 clinical medicine
topography
Ophthalmology
Aberrometry
Medicine
Pentacam hr
030304 developmental biology
Subclinical infection
0303 health sciences
Receiver operating characteristic
business.industry
Biomechanics
General Medicine
medicine.disease
eye diseases
subclinical keratoconus
030221 ophthalmology & optometry
sense organs
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- riUAL. Repositorio Institucional de la Universidad de Almería, Universidad de Almería, Journal of Clinical Medicine, Volume 10, Issue 13, Journal of Clinical Medicine, Vol 10, Iss 2746, p 2746 (2021)
- Accession number :
- edsair.doi.dedup.....7fd5164cc1580dd6914cd5c31a260883