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Diagnosis of Subclinical Keratoconus with a Combined Model of Biomechanical and Topographic Parameters

Authors :
Gracia Castro-Luna
Antonio Pérez-Rueda
Diana Jiménez-Rodríguez
Source :
riUAL. Repositorio Institucional de la Universidad de Almería, Universidad de Almería, Journal of Clinical Medicine, Volume 10, Issue 13, Journal of Clinical Medicine, Vol 10, Iss 2746, p 2746 (2021)
Publication Year :
2021

Abstract

This study sought to develop a diagnostic model with aberrometry and biomechanical variables for subclinical keratoconus. The design was a cross-sectional study. The topographic data were obtained with a rotating Scheimpflug camera (Pentacam HR), and biomechanical data were obtained with Corvis ST. The study included 81 eyes distributed in 61 healthy corneas and 20 subclinical keratoconus (SCKC), defined as eyes with suspicious topographic findings, normal slit-lamp examination, and a manifestation of keratoconus. Analyses of the topographic and biomechanical data were performed, and a classifying model of SCKC was elaborated. The model for the diagnosis of SCKC includes posterior coma to 90°, Ambrósio’s Relational Thickness in the horizontal profile (ARTh), and velocity when the air pulse is off (A2 velocity). The sensitivity was 89.5%, specificity 96.7%, accuracy 94.9%, and precision 89.5%. The area under the curve (AUC) of the receiver operating characteristic (ROC) curve for the model was 0.951. Diagnosis of subclinical keratoconus depends on the aberrometry variable posterior coma to 90° and the biomechanical variables A2 velocity and ARTh.

Details

Language :
English
Database :
OpenAIRE
Journal :
riUAL. Repositorio Institucional de la Universidad de Almería, Universidad de Almería, Journal of Clinical Medicine, Volume 10, Issue 13, Journal of Clinical Medicine, Vol 10, Iss 2746, p 2746 (2021)
Accession number :
edsair.doi.dedup.....7fd5164cc1580dd6914cd5c31a260883