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Prospective study on clinical characteristics of Japanese diabetic patients with chronic limb-threatening ischemia presenting Fontaine stage IV
- Source :
- Diabetol Int
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- The aim of this prospective cross-sectional study was to reveal clinical characteristics of Japanese diabetic patients with chronic limb-threatening ischemia (CLTI) presenting ischemic unhealed ulcer/gangrene (Fontaine stage IV) in the real-world settings. The present study included 132 Japanese diabetic patients who underwent endovascular therapy for CLTI presenting Fontaine stage IV. The prevalence of diabetes-related complications, as well as prior history of ankle-brachial index (ABI) measurement before CLTI onset, was evaluated adopting multiple imputation (50 times). Duration of diabetes was referred to as time from diagnosis. The patients were aged 70 ± 10 years, with duration of diabetes 23 ± 12 years. The diabetes-related complications were so common that only 17% (95% confidence interval: 11–24%) and 25% (17–33%) of the population were free from advanced micro- and macroangiopathies, respectively. The clustering of advanced macroangiopathies was not significantly associated with duration of diabetes (P = 0.62). On the other hand, that of advanced microangiopathies was significantly positively associated with duration of diabetes (P = 0.004). However, even in patients with duration of diabetes
- Subjects :
- Gangrene
medicine.medical_specialty
education.field_of_study
business.industry
Endocrinology, Diabetes and Metabolism
Microangiopathy
Population
Ischemia
030209 endocrinology & metabolism
030204 cardiovascular system & hematology
medicine.disease
Confidence interval
03 medical and health sciences
0302 clinical medicine
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Original Article
Prospective cohort study
Stage iv
education
business
Subjects
Details
- ISSN :
- 21901686 and 21901678
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Diabetology International
- Accession number :
- edsair.doi.dedup.....7fd4ed9b58f63427c5003e8ab0ca5205