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Maternal Obesity, Cage Density, and Age Contribute to Prostate Hyperplasia in Mice
- Source :
- Reproductive Sciences. 23:176-185
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- Identification of modifiable risk factors is gravely needed to prevent adverse prostate health outcomes. We previously developed a murine precancer model in which exposure to maternal obesity stimulated prostate hyperplasia in offspring. Here, we used generalized linear modeling to evaluate the influence of additional environmental covariates on prostate hyperplasia. As expected from our previous work, the model revealed that aging and maternal diet-induced obesity (DIO) each correlated with prostate hyperplasia. However, prostate hyperplasia was not correlated with the length of maternal DIO. Cage density positively associated with both prostate hyperplasia and offspring body weight. Expression of the glucocorticoid receptor in prostates also positively correlated with cage density and negatively correlated with age of the animal. Together, these findings suggest that prostate tissue was adversely patterned during early life by maternal overnutrition and was susceptible to alteration by environmental factors such as cage density. Additionally, prostate hyperplasia may be acutely influenced by exposure to DIO, rather than occurring as a response to worsening obesity and comorbidities experienced by the mother. Finally, cage density correlated with both corticosteroid receptor abundance and prostate hyperplasia, suggesting that overcrowding influenced offspring prostate hyperplasia. These results emphasize the need for multivariate regression models to evaluate the influence of coordinated variables in complicated animal systems.
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Offspring
Prostatic Hyperplasia
Corticosteroid receptor
03 medical and health sciences
Receptors, Glucocorticoid
Overnutrition
Glucocorticoid receptor
Pregnancy
Risk Factors
Prostate
Internal medicine
medicine
Animals
Obesity
business.industry
Age Factors
Obstetrics and Gynecology
Original Articles
medicine.disease
Housing, Animal
030104 developmental biology
Endocrinology
medicine.anatomical_structure
Prostate hyperplasia
Prenatal Exposure Delayed Effects
Female
business
Subjects
Details
- ISSN :
- 19337205 and 19337191
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Reproductive Sciences
- Accession number :
- edsair.doi.dedup.....7fd4b6b3c3c4c24a25b17d096f039a3f