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Hippocampal volume is an independent predictor of cognitive performance in CADASIL
- Source :
- Neurobiology of Aging. 30:890-897
- Publication Year :
- 2009
- Publisher :
- Elsevier BV, 2009.
-
Abstract
- Recent evidence suggests that hippocampal changes are present in vascular cognitive impairment but their importance and relationship with ischaemic mechanisms remain controversial. To investigate these issues we performed MRI and cognitive assessment in a large cohort (n = 144) of patients with CADASIL, a hereditary small vessel disease and model of pure vascular cognitive impairment. Dementia status was ascribed according to DSM-IV and global cognitive function assessed with the Minimental State Examination (MMSE) and Mattis Dementia Rating Scale (MDRS). Hippocampalvolume (HV) correlated with age (r = −0.33, p < 0.001), brain volume (r = 0.39, p < 0.001) and lacunar lesion volume (r = −0.23, p = 0.008), but not white matter lesions or microhaemorrhages. HV was reduced in dementia (2272 ± 333 mm3 versus 2642 ± 349 mm3, p < 0.001) in the whole cohort and the subgroup progressing to dementia before age 60. HV correlated with MMSE (r = 0.30, p < 0.001), MDRS (r = 0.40, p < 0.001) and in a multivariate model predicted cognition independent of typical vascular lesions and whole brain atrophy. These findings strengthen the view that hippocampal atrophy is an important pathway of cognitive impairment in vascular as well as degenerative disease.
- Subjects :
- Male
Aging
medicine.medical_specialty
Pathology
Statistics as Topic
CADASIL
Hippocampus
Sensitivity and Specificity
Article
Central nervous system disease
Cognition
Imaging, Three-Dimensional
Atrophy
Degenerative disease
Internal medicine
medicine
Humans
Dementia
Vascular dementia
General Neuroscience
Reproducibility of Results
Organ Size
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Hyperintensity
Cardiology
Female
Neurology (clinical)
Geriatrics and Gerontology
Cognition Disorders
Psychology
Developmental Biology
Subjects
Details
- ISSN :
- 01974580
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Neurobiology of Aging
- Accession number :
- edsair.doi.dedup.....7fd1da4e3208dab7a6440bb8054c2f60