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Two new cycloartanes from the leaves of Combretum quadrangulare growing in Vietnam and their biological activities
- Source :
- Arabian Journal of Chemistry, Vol 14, Iss 7, Pp 103189-(2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- Two new cycloartanes, combretanones G and H (1 and 2), were isolated from the leaves of Combretum quadrangulare. Their structures were elucidated by applying a set of spectroscopic methods, while their relative configurations were determined using DFT-NMR chemical shift calculations and subsequent assignment of DP4 probabilities. Compounds 1 and 2 are C-23/C-24 stereoisomers of the previously-reported euphonerin E. Both exhibited moderate cytotoxicity against three human cancer cell lines. Compound 2 was shown to be a potent antiparasitic. Our results confirm the traditional medicinal uses of Combretum quadrangulare in Vietnam.
- Subjects :
- Antiparasitic
medicine.drug_class
General Chemical Engineering
Cytotoxicity
02 engineering and technology
010402 general chemistry
01 natural sciences
Antiparasitic activity
Combretaceae
medicine
Combretum quadrangulare
QD1-999
biology
Traditional medicine
Chemistry
General Chemistry
021001 nanoscience & nanotechnology
biology.organism_classification
Combretanones G and H
0104 chemical sciences
Cycloartane
0210 nano-technology
Human cancer
Subjects
Details
- Language :
- English
- ISSN :
- 18785352
- Volume :
- 14
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Arabian Journal of Chemistry
- Accession number :
- edsair.doi.dedup.....7fcb0ee7afe902756208304c85f33d99