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Anti-lipopolysaccharide antibody mitigates ruminal lipopolysaccharide release without acute-phase inflammation or liver transcriptomic responses in Holstein bulls

Authors :
Keiichiro Kizaki
Hitoshi Mizuguchi
Yo Han Kim
Shiro Kushibiki
Atsushi Kimura
Shigeru Sato
Kentaro Ikuta
Source :
Journal of Veterinary Science
Publication Year :
2021

Abstract

Anti-lipopolysaccharide (LPS) antibody administration has the potential benefits of neutralizing and consequently controlling rumen-derived LPS during subacute ruminal acidosis. Four Holstein bulls were used in this crossover study with a 2-week wash-out period. Anti-LPS antibody (0 or 4 g) was administered once daily for 14 days. Significantly lower ruminal LPS and higher 1-h mean ruminal pH were identified in the 4 g group. However, blood metabolites, acute-phase proteins, cytokines, and hepatic transcriptomes were not different between the two groups. Therefore, anti-LPS antibody administration mitigated ruminal LPS release and pH depression without accompanying responses in acute-phase inflammation or hepatic transcriptomic expression.

Details

ISSN :
1976555X
Volume :
22
Issue :
3
Database :
OpenAIRE
Journal :
Journal of veterinary science
Accession number :
edsair.doi.dedup.....7fa8affe13483bdee8632404d9250f8f