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Anti-lipopolysaccharide antibody mitigates ruminal lipopolysaccharide release without acute-phase inflammation or liver transcriptomic responses in Holstein bulls
- Source :
- Journal of Veterinary Science
- Publication Year :
- 2021
-
Abstract
- Anti-lipopolysaccharide (LPS) antibody administration has the potential benefits of neutralizing and consequently controlling rumen-derived LPS during subacute ruminal acidosis. Four Holstein bulls were used in this crossover study with a 2-week wash-out period. Anti-LPS antibody (0 or 4 g) was administered once daily for 14 days. Significantly lower ruminal LPS and higher 1-h mean ruminal pH were identified in the 4 g group. However, blood metabolites, acute-phase proteins, cytokines, and hepatic transcriptomes were not different between the two groups. Therefore, anti-LPS antibody administration mitigated ruminal LPS release and pH depression without accompanying responses in acute-phase inflammation or hepatic transcriptomic expression.
- Subjects :
- Lipopolysaccharides
Male
Rumen
Lipopolysaccharide
Cattle Diseases
Immunoglobulins
Inflammation
Pharmacology
Transcriptome
chemistry.chemical_compound
medicine
Internal Medicine
Animals
subacute ruminal acidosis
Acute-Phase Reaction
General Veterinary
biology
Crossover study
Subacute ruminal acidosis
rumen fermentation
chemistry
Liver
cattle
Fermentation
Anti-lipopolysaccharide antibody
biology.protein
lipids (amino acids, peptides, and proteins)
Antibody
medicine.symptom
Once daily
liver transcriptome
Acidosis
Rapid Communication
Subjects
Details
- ISSN :
- 1976555X
- Volume :
- 22
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of veterinary science
- Accession number :
- edsair.doi.dedup.....7fa8affe13483bdee8632404d9250f8f