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Coexistence of chronic lymphocytic thyroiditis and papillary thyroid carcinoma. Impact on presentation, management, and outcome
- Source :
- International journal of surgery (London, England). 28
- Publication Year :
- 2015
-
Abstract
- Background: The association between chronic lymphocytic thyroiditis (CLT) and papillary thyroid car- cinoma (PTC) has been investigated for several years from different perspectives. In spite of that, there were only few attempts to design a common frame of references to understand the complex mutual interactions between the various pathways of inflammatory response and of thyroid tumor induction and progression. This study compares two independent groups of patients aiming to determine the frequency and the prognostic significance of CLT in patients with PTC. Material and methods: From January 2005 to September 2013, we conducted a retrospective study on 160 patients with PTC who underwent thyroidectomy. CLT was diagnosed histopathologically. Age, sex, tu- mor features (dimensions, angioinvasion, capsular infiltration, mono/multifocality and lymph node metastases) pathologic findings and outcome were considered. Mean follow-up (metastasis, completeness-of-resection, serum thyroglobulin levels, tumor recurrence) period was 61 months (ranged from 18 to 132 months). A p < 0.05 was considered statistically significant. Results: Patients were divided in 2 groups. In group A there were 90 patients affected by PTC alone, and in group B there were 70 patients affected with PTC associated with CLT. Our data showed that the presence of CLT correlate with a lower grade of PTC (p < 0.05). Considering the sex of the patients there were a statistically significant correlation (p < 0.02) and the presence of CLT associated with PTC was most representative in female patients. Conclusions: The presence of CLT in patients with PTC correlated with a lower grade of PTC, but it does not affect the overall survival of papillary thyroid cancers.
- Subjects :
- Adult
Male
medicine.medical_specialty
Pathology
endocrine system diseases
Adolescent
medicine.medical_treatment
030209 endocrinology & metabolism
Gastroenterology
Thyroiditis
Metastasis
Thyroid carcinoma
03 medical and health sciences
Young Adult
0302 clinical medicine
Internal medicine
medicine
Carcinoma
Humans
Neoplasm Invasiveness
Thyroid Neoplasms
Child
Thyroid cancer
Aged
Retrospective Studies
Aged, 80 and over
business.industry
Thyroid
Thyroidectomy
Thyroiditis, Autoimmune
General Medicine
Middle Aged
medicine.disease
Prognosis
Carcinoma, Papillary
medicine.anatomical_structure
Thyroid Cancer, Papillary
030220 oncology & carcinogenesis
Lymphatic Metastasis
Surgery
Female
Neoplasm Grading
business
Lymphocytic Thyroiditis
Subjects
Details
- ISSN :
- 17439159
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- International journal of surgery (London, England)
- Accession number :
- edsair.doi.dedup.....7fa6e1188b3ee273a9c9dd77cb931e8a