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The Chemokine Growth-Regulated Oncogene-α Promotes Spinal Cord Oligodendrocyte Precursor Proliferation
- Source :
- The Journal of Neuroscience. 18:10457-10463
- Publication Year :
- 1998
- Publisher :
- Society for Neuroscience, 1998.
-
Abstract
- Chemokines, (chemotactic cytokines) are a family of regulatory molecules involved in modulating inflammatory responses. Here we demonstrate that the chemokine growth-regulated oncogene-alpha (GRO-alpha) is a potent promoter of oligodendrocyte precursor proliferation. The proliferative response of immature spinal cord oligodendrocyte precursors to their major mitogen, platelet derived growth factor (PDGF), is dramatically enhanced by GRO-alpha present in spinal cord conditioned medium. One source of GRO-alpha is a subset of spinal cord astrocytes. Cultures of astrocytes contain GRO-alpha mRNA and protein and secrete biologically active concentrations of GRO-alpha. In postnatal spinal cord white matter the location of GRO-alpha-immunoreactive cells is developmentally regulated: GRO-alpha+ cells first appear in ventral and later in dorsal spinal cord white matter. These results suggest that localized proliferation of oligodendrocytes is mediated by synergy between PDGF and GRO-alpha.
- Subjects :
- Chemokine
Platelet-derived growth factor
Chemokine CXCL1
Article
chemistry.chemical_compound
Gangliosides
medicine
Animals
RNA, Messenger
Growth Substances
Cells, Cultured
Platelet-Derived Growth Factor
Chemotactic Factors
Dose-Response Relationship, Drug
biology
Oncogene
Stem Cells
General Neuroscience
Gene Expression Regulation, Developmental
Drug Synergism
Spinal cord
Oligodendrocyte
Rats
Cell biology
Oligodendroglia
medicine.anatomical_structure
Spinal Cord
chemistry
Astrocytes
Culture Media, Conditioned
GDF7
Mitogen-activated protein kinase
Immunology
biology.protein
Intercellular Signaling Peptides and Proteins
lipids (amino acids, peptides, and proteins)
Chemokines, CXC
Cell Division
Platelet-derived growth factor receptor
Subjects
Details
- ISSN :
- 15292401 and 02706474
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- The Journal of Neuroscience
- Accession number :
- edsair.doi.dedup.....7f8fcae52d1317c3c65c6f0137a63bf5