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CD8+ Lymphogranulomatous Dermatitis as a Manifestation of Malignancy-Associated Immunodeficiency: Rethinking Paraneoplastic Granulomas
- Source :
- The American Journal of Dermatopathology. 43:e222-e226
- Publication Year :
- 2021
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2021.
-
Abstract
- Paraneoplastic granulomatous disease occurs in approximately 7.3% of patients with non-Hodgkin lymphoma, most commonly among patients with chronic lymphocytic leukemia (CLL). These lesions are often reported to appear similar to sarcoidosis in clinical presentation and under light microscopy. However, comprehensive descriptions of the cytomorphologic characteristics of these paraneoplastic granulomas are lacking, and the mechanisms involved in their formation remain ill-defined. Noninfectious dermal granulomatous reactions have also been reported in many primary immunodeficiencies, including common variable immune deficiency and ataxia-telangiectasia. We present a case of noninfectious CD8+ predominant granulomatous dermatitis with ocular involvement occurring in the setting of CLL and marked hypogammaglobulinemia. Based on the analysis of shared factors in patients with primary immunodeficiencies and CLL, we conclude that the presence of pan-humoral immunodeficiency could itself be a risk factor for developing a CD8+ lymphogranulomatous reaction. This report and associated discussion evince that CD8+ predominant granulomatous reactions, distinct from sarcoidosis, may represent a previously unappreciated segment of the paraneoplastic granulomas observed in hematologic malignancies.
- Subjects :
- Male
Pathology
medicine.medical_specialty
Paraneoplastic Syndromes
Chronic lymphocytic leukemia
Dermatitis
Dermatology
CD8-Positive T-Lymphocytes
Malignancy
Pathology and Forensic Medicine
Hypogammaglobulinemia
Immunocompromised Host
hemic and lymphatic diseases
Humans
Medicine
Immunodeficiency
Aged
Granuloma
business.industry
Common variable immunodeficiency
General Medicine
medicine.disease
Leukemia, Lymphocytic, Chronic, B-Cell
Lymphoma
Sarcoidosis
business
Granulomatous Dermatitis
Subjects
Details
- ISSN :
- 01931091
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- The American Journal of Dermatopathology
- Accession number :
- edsair.doi.dedup.....7f8ace6fce0c0804a0a849247da84099
- Full Text :
- https://doi.org/10.1097/dad.0000000000002068