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Natural and Synthetic Polymers for Bone Scaffolds Optimization
- Source :
- Polymers, Polymers, Vol 12, Iss 905, p 905 (2020)
- Publication Year :
- 2020
- Publisher :
- MDPI, 2020.
-
Abstract
- Bone tissue is the structural component of the body, which allows locomotion, protects vital internal organs, and provides the maintenance of mineral homeostasis. Several bone-related pathologies generate critical-size bone defects that our organism is not able to heal spontaneously and require a therapeutic action. Conventional therapies span from pharmacological to interventional methodologies, all of them characterized by several drawbacks. To circumvent these effects, tissue engineering and regenerative medicine are innovative and promising approaches that exploit the capability of bone progenitors, especially mesenchymal stem cells, to differentiate into functional bone cells. So far, several materials have been tested in order to guarantee the specific requirements for bone tissue regeneration, ranging from the material biocompatibility to the ideal 3D bone-like architectural structure. In this review, we analyse the state-of-the-art of the most widespread polymeric scaffold materials and their application in in vitro and in vivo models, in order to evaluate their usability in the field of bone tissue engineering. Here, we will present several adopted strategies in scaffold production, from the different combination of materials, to chemical factor inclusion, embedding of cells, and manufacturing technology improvement.
- Subjects :
- Scaffold
polymeric scaffold
Polymers and Plastics
Biocompatibility
Computer science
0206 medical engineering
02 engineering and technology
Review
Bone tissue
Regenerative medicine
lcsh:QD241-441
lcsh:Organic chemistry
Tissue engineering
natural polymers
Bone cell
medicine
synthetic polymers
bone tissue engineering
natural polymer
Regeneration (biology)
Mesenchymal stem cell
General Chemistry
021001 nanoscience & nanotechnology
bone tissue regeneration
020601 biomedical engineering
3. Good health
medicine.anatomical_structure
polymeric scaffold, natural polymers, synthetic polymers, bone tissue engineering, bone tissue regeneration
synthetic polymer
0210 nano-technology
Biomedical engineering
Subjects
Details
- Language :
- English
- ISSN :
- 20734360
- Volume :
- 12
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Polymers
- Accession number :
- edsair.doi.dedup.....7f76761f9196250d81586c98966ee27b