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Heme Oxygenase-1 as a Target for the Design of Gene and Pharmaceutical Therapies for Autoimmune Diseases
- Source :
- CURRENT GENE THERAPY, Artículos CONICYT, CONICYT Chile, instacron:CONICYT
- Publication Year :
- 2014
- Publisher :
- Bentham Science Publishers Ltd., 2014.
-
Abstract
- One of the major goals in the research of autoimmune diseases is to develop specific therapies to regulate the expression and function of gene products that could contribute to restoring tolerance to self-constituents and replace conventional systemic immunosuppression, which is associated with important undesired side effects. Although significant progress has been made on the understanding of the pathogenesis of autoimmunity, therapies for these ailments have not seen a change. During the last decade, different strategies such as pharmacologic or gene therapy modulation of heme oxygenase-1 (HO-1) and the administration of its metabolic product, carbon monoxide (CO), have been shown to display beneficial immunoregulatory and cytoprotective properties. In different experimental autoimmune conditions, such as Experimental autoimmune encephalomyelitis, type-1 diabetes and systemic lupus erythematosus, genetic or pharmacological modulation of HO-1, as well as delivery of CO have shown to ameliorate disease progression. Furthermore, it has been demonstrated that dendritic cell and monocyte function can be modulated by HO-1 and/or CO. In this article, recent data related to the immunoregulatory properties of HO-1/CO will be discussed, focusing on their potential therapeutic use to treat autoimmune diseases.
- Subjects :
- Cell Survival
Genetic enhancement
medicine.disease_cause
Autoimmune Diseases
Autoimmunity
Pathogenesis
Diabetes mellitus
Drug Discovery
Genetics
medicine
Animals
Humans
Molecular Biology
Genetics (clinical)
Carbon Monoxide
business.industry
Monocyte
Experimental autoimmune encephalomyelitis
Genetic Therapy
Dendritic cell
medicine.disease
Heme oxygenase
Disease Models, Animal
medicine.anatomical_structure
Gene Targeting
Immunology
Molecular Medicine
business
Heme Oxygenase-1
Subjects
Details
- ISSN :
- 15665232
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Current Gene Therapy
- Accession number :
- edsair.doi.dedup.....7f714be0893ed5bcc3bf345541ac3362