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Structural Alteration in Dermal Vessels and Collagen Bundles following Exposure of Skin Wound to Zeolite–Bentonite Compound
- Source :
- Journal of Pharmaceutics, Vol 2016 (2016), Journal of Pharmaceutics
- Publication Year :
- 2016
- Publisher :
- Hindawi Publishing Corporation, 2016.
-
Abstract
- Background. This study examines the impact of one-time direct application of haemostatic agent zeolite–bentonite powder to wounded skin on the healing process in rats. Materials and Methods. 24 male Sprague-Dawley rats were randomly allocated into two groups (n=12): (1) the rats whose wounds were washed only with sterile normal saline (NS-treated) and (2) those treated with zeolite–bentonite compound (ZEO-treated). The wound was circular, full-thickness, and 2 cm in diameter. At the end of the 12th day, six animals from each group were randomly selected and terminated. The remaining rats were terminated after 21 days. Just after scarification, skin samples were excised and sent for stereological evaluation. Results. The results showed a significant difference between the two groups regarding the length density of the blood vessels and diameter of the large and small vessels on the 12th day after the wound was inflicted. Besides, volume density of both the dermis and collagen bundles was reduced by 25% in the ZEO-treated rats in comparison to the NS-treated animals after 21 days. Conclusions. One-time topical usage of zeolite–bentonite haemostatic powder on an animal skin wound might negatively affect the healing process through vasoconstriction and inhibition of neoangiogenesis.
- Subjects :
- medicine.medical_specialty
Pathology
Materials science
Skin wound
integumentary system
Article Subject
Length density
medicine.medical_treatment
Significant difference
030232 urology & nephrology
lcsh:RS1-441
030208 emergency & critical care medicine
Volume density
Surgery
lcsh:Pharmacy and materia medica
03 medical and health sciences
0302 clinical medicine
medicine.anatomical_structure
Dermis
medicine
medicine.symptom
Saline
Scarification
Vasoconstriction
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 20909918
- Database :
- OpenAIRE
- Journal :
- Journal of Pharmaceutics
- Accession number :
- edsair.doi.dedup.....7f68882df870b862e949c8fa51bfec98
- Full Text :
- https://doi.org/10.1155/2016/5843459