Back to Search
Start Over
Sequence-specific cleavage of yeast tRNA(Phe) with oligonucleotides conjugated to a diimidazole construct
- Source :
- Antisensenucleic acid drug development. 7(1)
- Publication Year :
- 1997
-
Abstract
- Oligonucleotide derivatives conjugated to a chemical construction with two histamine residues imitating the catalytic center of ribonuclease A have been synthesized. In experiments with the conjugates complementary to the 3'-end and to the variable loop and the T loop of yeast tRNA(Phe), it was shown that the compounds can accomplish sequence-specific cleavage of the target RNA in physiologic conditions.
Details
- ISSN :
- 10872906
- Volume :
- 7
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Antisensenucleic acid drug development
- Accession number :
- edsair.doi.dedup.....7f67cb9f8bd9b927b224a9b28c5e8d74