Back to Search
Start Over
Striatal dopamine release and biphasic pattern of locomotor and motor activity under gas narcosis
- Source :
- Life Sciences. 72:2731-2740
- Publication Year :
- 2003
- Publisher :
- Elsevier BV, 2003.
-
Abstract
- Inert gas narcosis is a neurological syndrome appearing when humans or animals are exposed to hyperbaric inert gases (nitrogen, argon) composed by motor and cognitive impairments. Inert gas narcosis induces a decrease of the dopamine release at the striatum level, structure involved in the regulation of the extrapyramidal motricity. We have investigated, in freely moving rats exposed to different narcotic conditions, the relationship between the locomotor and motor activity and the striatal dopamine release, using respectively a computerized device that enables a quantitative analysis of this behavioural disturbance and voltammetry. The use of 3 MPa of nitrogen, 2 MPa of argon and 0.1 MPa of nitrous oxide, revealed after a transient phase of hyperactivity, a lower level of the locomotor and motor activity, in relation with the decrease of the striatal dopamine release. It is concluded that the striatal dopamine decrease could be related to the decrease of the locomotor and motor hyperactivity, but that other(s) neurotransmitter(s) could be primarily involved in the behavioural motor disturbances induced by narcotics. This biphasic effect could be of major importance for future pharmacological investigations, and motor categorization, on the basic mechanisms of inert gas at pressure.
- Subjects :
- Male
medicine.medical_specialty
Light
Nitrogen
Narcotic
Dopamine
medicine.medical_treatment
Nitrous Oxide
Striatum
Motor Activity
General Biochemistry, Genetics and Molecular Biology
Rats, Sprague-Dawley
chemistry.chemical_compound
Internal medicine
Electrochemistry
medicine
Animals
Motor activity
Argon
General Pharmacology, Toxicology and Pharmaceutics
Inert gas
Neurotransmitter
Electrodes
Chemistry
General Medicine
Nitrous oxide
Darkness
Rats
Neostriatum
Atmospheric Pressure
Endocrinology
Inert Gas Narcosis
Stereotyped Behavior
Neuroscience
medicine.drug
Subjects
Details
- ISSN :
- 00243205
- Volume :
- 72
- Database :
- OpenAIRE
- Journal :
- Life Sciences
- Accession number :
- edsair.doi.dedup.....7f60e1081ddea1173e4281072a446555