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Network architecture and regulatory logic in neural crest development
- Source :
- Wiley Interdiscip Rev Syst Biol Med
- Publication Year :
- 2019
-
Abstract
- The neural crest is an ectodermal cell population that gives rise to over 30 cell types during vertebrate embryogenesis. These stem cells are formed at the border of the developing central nervous system and undergo extensive migration before differentiating into components of multiple tissues and organs. Neural crest formation and differentiation is a multistep process, as these cells transition through sequential regulatory states before adopting their adult phenotype. Such changes are governed by a complex gene regulatory network (GRN) that integrates environmental and cell-intrinsic inputs to regulate cell identity. Studies of neural crest cells in a variety of vertebrate models have elucidated the function and regulation of dozens of the molecular players that are part of this network. The neural crest GRN has served as a platform to explore the molecular control of multipotency, cell differentiation, and the evolution of vertebrates. In this review, we employ this genetic program as a stepping-stone to explore the architecture and the regulatory principles of developmental GRNs. We also discuss how modern genomic approaches can further expand our understanding of genetic networks in this system and others. This article is categorized under: Physiology > Mammalian Physiology in Health and Disease Biological Mechanisms > Cell Fates Developmental Biology > Lineages Models of Systems Properties and Processes > Cellular Models.
- Subjects :
- Cell type
Epithelial-Mesenchymal Transition
Cellular differentiation
Population
Gene regulatory network
Medicine (miscellaneous)
Biology
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Article
03 medical and health sciences
0302 clinical medicine
Neural crest formation
Cell Movement
Animals
Gene Regulatory Networks
education
030304 developmental biology
0303 health sciences
education.field_of_study
Neural crest
Gene Expression Regulation, Developmental
Cell Differentiation
Biological Evolution
Neural Crest
Stem cell
Neuroscience
Developmental biology
030217 neurology & neurosurgery
Signal Transduction
Subjects
Details
- ISSN :
- 1939005X
- Volume :
- 12
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Wiley interdisciplinary reviews. Systems biology and medicine
- Accession number :
- edsair.doi.dedup.....7f530cc5bf9b53110b1843305c37f721