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Differential effects of lipoprotein apheresis by lipidfiltration or dextran sulfate adsorption on lipidomic profile
- Source :
- Atherosclerosis Supplements. 14:151-155
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- Objective and methods Acute modification of plasma lipidomic profile was assessed by top-down shotgun profiling on a LTQ Orbitrap hybrid mass spectrometer in 14 patients treated with two different apheresis techniques: plasma lipidfiltration (LF) and whole blood dextran sulfate adsorption (DSA). Results Patients treated with DSA revealed a significantly more pronounced reduction of LDL-cholesterol (LDL-C), a diminished decrease of HDL-cholesterol (HDL-C) and triglycerides (TG), and a similar reduction in lipoprotein (a) (Lp(a)) level. Against the overall tendency of reduction of lipid metabolites of all lipid classes in post-apheresis plasma, independent of apheresis technology applied, a highly significant increase of phosphatidylethanolamines (PE) in response to DSA was observed. Conclusion These data indicate that DSA technology may be associated with an activation or damage of blood cells at contact surface which subsequently leads to a massive liberation of cellular and membrane PE's. Pathophysiological consequences, especially with respect to coagulation system and oxidative stress, have to be further elucidated.
- Subjects :
- Male
Lipoproteins
Membrane lipids
Hyperlipidemias
Mass Spectrometry
chemistry.chemical_compound
Lipidomics
Hyperlipidemia
Internal Medicine
medicine
Humans
Metabolomics
Triglycerides
Aged
Whole blood
Aged, 80 and over
Analysis of Variance
Chromatography
biology
Cholesterol
Phosphatidylethanolamines
Cholesterol, HDL
Dextran Sulfate
Cholesterol, LDL
General Medicine
Lipoprotein(a)
Middle Aged
medicine.disease
Treatment Outcome
chemistry
Biochemistry
Blood Component Removal
biology.protein
Liberation
Female
lipids (amino acids, peptides, and proteins)
Adsorption
Cardiology and Cardiovascular Medicine
Biomarkers
Lipoprotein
Subjects
Details
- ISSN :
- 15675688
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Atherosclerosis Supplements
- Accession number :
- edsair.doi.dedup.....7f513a41a5a46772a6abd21de92f8f8e