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Transcriptional Profiling of Immune and Inflammatory Responses in the Context of SARS-CoV-2 Fungal Superinfection in a Human Airway Epithelial Model
- Source :
- Microorganisms; Volume 8; Issue 12; Pages: 1974, Microorganisms, Vol 8, Iss 1974, p 1974 (2020), Microorganisms, Microorganisms, MDPI, 2020, ⟨10.1101/2020.05.19.103630⟩, Microorganisms, 2020, ⟨10.1101/2020.05.19.103630⟩
- Publication Year :
- 2020
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2020.
-
Abstract
- Superinfections of bacterial/fungal origin are known to affect the course and severity of respiratory viral infections. An increasing number of evidence indicate a relatively high prevalence of superinfections associated with COVID-19, including invasive aspergillosis, but the underlying mechanisms remain to be characterized. In the present study, to better understand the biological impact of superinfection we sought to determine and compare the host transcriptional response to SARS-CoV-2 versusAspergillussuperinfection, using a model of reconstituted humain airway epithelium. Our analyses reveal that both simple infection and superinfection induce a strong deregulation of core components of innate immune and inflammatory responses, with a stronger response to superinfection in the bronchial epithelial model compared to its nasal counterpart. Our results also highlight unique transcriptional footprints of SARS-CoV-2Aspergillussuperinfection, such as an imbalanced type I/type III IFN, and an induction of several monocyte- and neutrophil associated chemokines, that could be useful for the understanding ofAspergillus-associated COVID-19 and but also management of severe forms of aspergillosis in this specific context.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
Chemokine
viruses
medicine.disease_cause
Aspergillosis
Microbiology
Article
03 medical and health sciences
0302 clinical medicine
Immune system
Virology
parasitic diseases
medicine
lcsh:QH301-705.5
transcriptional profiling
030304 developmental biology
invasive aspergillosis
0303 health sciences
Aspergillus
Innate immune system
biology
SARS-CoV-2
Monocyte
COVID-19
virus diseases
biochemical phenomena, metabolism, and nutrition
biology.organism_classification
medicine.disease
Epithelium
3. Good health
030104 developmental biology
medicine.anatomical_structure
lcsh:Biology (General)
030220 oncology & carcinogenesis
Superinfection
[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology
Immunology
biology.protein
Respiratory epithelium
Subjects
Details
- Language :
- English
- ISSN :
- 20762607
- Database :
- OpenAIRE
- Journal :
- Microorganisms; Volume 8; Issue 12; Pages: 1974
- Accession number :
- edsair.doi.dedup.....7f45fdea87beed9d413ef9bb10768234
- Full Text :
- https://doi.org/10.3390/microorganisms8121974