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Expression of Epstein‐Barr Virus Latent Genes in Oral Epithelium: Determinants of the Pathogenesis of Oral Hairy Leukoplakia

Authors :
Paul D. Ling
Alexey V. Gordadze
C. Mark Nichols
Miguel Monter-Wlaters
Dennis M. Walling
Catherine M. Flaitz
Source :
The Journal of Infectious Diseases. 190:396-399
Publication Year :
2004
Publisher :
Oxford University Press (OUP), 2004.

Abstract

This retrospective study examined expression of Epstein-Barr virus (EBV) latent genes in oral epithelium from human immunodeficiency virus-seropositive subjects, to identify genes associated with the pathogenesis of oral hairy leukoplakia (HLP). Transcription of EBV latent genes was detected in tissues with productive EBV replication and, also, in normal oral epithelial tissues without EBV replication. Expression of the EBV EBNA-2 open-reading frame in oral epithelium was identified as an important cofactor associated with the pathogenesis of HLP. In vitro experiments suggested that a recombinant variant of the EBNA-2 gene may play a role in the pathogenesis of HLP, through modulation of EBNA-2 protein function.

Details

ISSN :
15376613 and 00221899
Volume :
190
Database :
OpenAIRE
Journal :
The Journal of Infectious Diseases
Accession number :
edsair.doi.dedup.....7f417cdf27a219a6d0c467376ebe59f5
Full Text :
https://doi.org/10.1086/422039