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Expression of Epstein‐Barr Virus Latent Genes in Oral Epithelium: Determinants of the Pathogenesis of Oral Hairy Leukoplakia
- Source :
- The Journal of Infectious Diseases. 190:396-399
- Publication Year :
- 2004
- Publisher :
- Oxford University Press (OUP), 2004.
-
Abstract
- This retrospective study examined expression of Epstein-Barr virus (EBV) latent genes in oral epithelium from human immunodeficiency virus-seropositive subjects, to identify genes associated with the pathogenesis of oral hairy leukoplakia (HLP). Transcription of EBV latent genes was detected in tissues with productive EBV replication and, also, in normal oral epithelial tissues without EBV replication. Expression of the EBV EBNA-2 open-reading frame in oral epithelium was identified as an important cofactor associated with the pathogenesis of HLP. In vitro experiments suggested that a recombinant variant of the EBNA-2 gene may play a role in the pathogenesis of HLP, through modulation of EBNA-2 protein function.
- Subjects :
- Gene Expression Regulation, Viral
Hairy leukoplakia
Herpesvirus 4, Human
Leukoplakia, Hairy
Genes, Viral
Transcription, Genetic
Biopsy
Acyclovir
HIV Infections
Biology
Virus Replication
medicine.disease_cause
Epithelium
Virus
Herpesviridae
Viral Matrix Proteins
Pathogenesis
Viral Proteins
hemic and lymphatic diseases
medicine
Humans
Immunology and Allergy
Gammaherpesvirinae
RNA, Messenger
Gene
Retrospective Studies
Oral hairy leukoplakia
Mouth Mucosa
Valine
biology.organism_classification
medicine.disease
Epstein–Barr virus
Virology
stomatognathic diseases
Infectious Diseases
Epstein-Barr Virus Nuclear Antigens
Valacyclovir
Immunology
RNA, Viral
Subjects
Details
- ISSN :
- 15376613 and 00221899
- Volume :
- 190
- Database :
- OpenAIRE
- Journal :
- The Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....7f417cdf27a219a6d0c467376ebe59f5
- Full Text :
- https://doi.org/10.1086/422039