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IL-17RA in Non-Hematopoietic Cells Controls CXCL-1 and 5 Critical to Recruit Neutrophils to the Lung of Mycobacteria-Infected Mice during the Adaptive Immune Response
- Source :
- PLoS ONE, PLoS ONE, Vol 11, Iss 2, p e0149455 (2016), PLoS ONE, Public Library of Science, 2016, 11 (2), pp.1-18. ⟨10.1371/journal.pone.0149455⟩, Plos One 2 (11), 1-18. (2016)
- Publication Year :
- 2016
- Publisher :
- Public Library of Science (PLoS), 2016.
-
Abstract
- During chronic infection with Mycobacterium tuberculosis (Mtb), bacilli multiplication is constrained within lung granulomas until excessive inflammation destroys the lung. Neutrophils are recruited early and participate in granuloma formation, but excessive neutrophilia exacerbates the tuberculosis disease. Neutrophils thus appear as potential targets for therapeutic interventions, especially in patients for whom no antibiotic treatment is possible. Signals that regulate neutrophil recruitment to the lung during mycobacterial infection need to be better understood. We demonstrated here, in the mouse model, that neutrophils were recruited to the lung in two waves after intranasal infection with virulent Mtb or the live attenuated vaccine strain Bacillus Calmette Guérin (BCG). A first wave of neutrophils was swiftly recruited, followed by a subsequent adaptive wave that reached the lung together with IFN-γ- and IL-17A-producing T cells. Interestingly, the second neutrophil wave did not participate to mycobacteria control in the lung and established contacts with T cells. The adaptive wave was critically dependent on the expression of IL-17RA, the receptor for IL-17A, expressed in non-hematopoietic cells. In absence of this receptor, curtailed CXCL-1 and 5 production in the lung restrained neutrophil recruitment. CXCL-1 and 5 instillation reconstituted lung neutrophil recruitment in BCG-infected IL17RA-/- mice.
- Subjects :
- Male
0301 basic medicine
neutrophile
Chemokine CXCL5
Chemokine
infection expérimentale
Neutrophils
[SDV]Life Sciences [q-bio]
Chemokine CXCL1
lcsh:Medicine
souris
White Blood Cells
Mice
Spectrum Analysis Techniques
0302 clinical medicine
Animal Cells
Medicine and Health Sciences
mycobactérie
lcsh:Science
Immune Response
Lung
Receptors, Interleukin-17
Multidisciplinary
T Cells
Chemotaxis
Animal Models
respiratory system
Flow Cytometry
Acquired immune system
3. Good health
Actinobacteria
Cell Motility
medicine.anatomical_structure
Neutrophil Infiltration
Spectrophotometry
Granulomas
BCG Vaccine
Cytophotometry
Cellular Types
Chemokines
medicine.symptom
Research Article
Tuberculosis
Immune Cells
réponse immunitaire
Immunology
Mouse Models
Inflammation
Biology
Research and Analysis Methods
03 medical and health sciences
Model Organisms
Immune system
medicine
Animals
Humans
Tuberculosis, Pulmonary
Blood Cells
Bacteria
lcsh:R
Organisms
Biology and Life Sciences
Cell Biology
Mycobacterium tuberculosis
medicine.disease
Neutrophilia
Mice, Inbred C57BL
030104 developmental biology
poumon
biology.protein
lcsh:Q
BCG vaccine
030215 immunology
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....7f379adcffdfeeecd05073aefe420bbd