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High Rate of MCR-1-Producing Escherichia coli and Klebsiella pneumoniae among Pigs, Portugal
- Source :
- Emerging infectious diseases, vol. 23, no. 12, pp. 2023-2029, Emerging Infectious Diseases, Vol 23, Iss 12, Pp 2023-2029 (2017), Emerging Infectious Diseases
- Publication Year :
- 2017
-
Abstract
- The mcr-1 (mobile colistin resistance 1) gene, which encodes phosphoethanolamine transferase, has been recently identified as a source of acquired resistance to polymyxins in Escherichia coli. Using the SuperPolymyxin selective medium, we prospectively screened 100 pigs at 2 farms in Portugal for polymyxin-resistant Enterobacteriaceae and recovered 98 plasmid-mediated MCR-1–producing isolates. Most isolates corresponded to nonclonally related E. coli belonging to many sequence types; we also found 2 Klebsiella pneumoniae sequence types. The mcr-1 gene was carried on IncHI2 or IncP plasmid backbones. Our finding of a high rate of MCR-1 producers on 2 pig farms in Portugal highlights the diffusion of that colistin-resistance determinant at the farm level. The fact that the pigs received colistin as metaphylaxis in their feed during the 6 weeks before sampling suggests selective pressure.
- Subjects :
- 0301 basic medicine
Swine
Epidemiology
Klebsiella pneumoniae
Gene Dosage
Gene Expression
lcsh:Medicine
High Rate of MCR-1–Producing Escherichia coli and Klebsiella pneumoniae among Pigs, Portugal
medicine.disease_cause
Plasmid
colistin
bacteria
Escherichia coli Infections
biology
Escherichia coli Proteins
pigs
Enterobacteriaceae
Escherichia coli
Klebsiella pneumonia
MCR-1
Portugal
antimicrobial resistance
mcr-1 gene
Anti-Bacterial Agents
Infectious Diseases
Conjugation, Genetic
hormones, hormone substitutes, and hormone antagonists
Plasmids
medicine.drug
Microbiology (medical)
Farms
Gene Transfer, Horizontal
030106 microbiology
lcsh:Infectious and parasitic diseases
Microbiology
03 medical and health sciences
Antibiotic resistance
medicine
Animals
lcsh:RC109-216
Research
lcsh:R
Membrane Proteins
biology.organism_classification
medicine.disease
Klebsiella Infections
Colistin
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Emerging infectious diseases, vol. 23, no. 12, pp. 2023-2029, Emerging Infectious Diseases, Vol 23, Iss 12, Pp 2023-2029 (2017), Emerging Infectious Diseases
- Accession number :
- edsair.doi.dedup.....7f322a73060380f3d909a3283ffe43a3