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Dose-response associations of clinical markers of obesity and duration of exposure to excess weight with chronic musculoskeletal pain: cross-sectional analysis at baseline of ELSA-Brasil Musculoskeletal cohort
- Source :
- Rheumatology international. 40(6)
- Publication Year :
- 2020
-
Abstract
- The objective of this study is to investigate the association of clinical markers of obesity and weight trajectories with chronic musculoskeletal pain (CMP). This is a cross-sectional study using baseline data from ELSA-Brasil MSK cohort. CMP was evaluated at nine body sites (neck, shoulders, upper back, elbows, lower back, wrists/hands, hips/thighs, knees, ankles/feet), and defined as pain lasting > 6 months in the past year. General and abdominal obesity levels were classified according to accepted cut-offs for body mass index (BMI), waist circumference (WC) and waist–height ratio (WHtR). Binomial and multinomial logistic regressions tested for associations with CMP at any site, at ≥ 3 sites (multisite) and in upper + lower limbs + axial skeleton (generalized). A total of 2899 participants (mean age 56.0 ± 8.93) were included, 55.0% reported CMP, 19.1% had multisite, and 10.3% had generalized CMP. After adjustments for sex, age, education, physical activity and depressive symptoms, nearly all the investigated markers of obesity were associated with any CMP, multisite and generalized CMP, with strongest associations being observed for general obesity level II/III: OR 2.08 (95% CI 1.45–2.99), OR 3.19 (95% CI 2.06–4.94) and OR 3.65 (2.18–6.11), respectively. Having excess weight currently or both at age 20 and currently was also associated with all CMP presentations. Associations of greater magnitude were consistently observed at higher obesity levels and longer exposures to excess weight (dose–response). These results may support the contribution of obesity-derived mechanical and inflammatory mechanisms of CMP, and indicate a role for the accumulation of exposure to excess weight across the adult life course.
- Subjects :
- Adult
Male
medicine.medical_specialty
Waist
Cross-sectional study
Shoulders
Immunology
Body Mass Index
03 medical and health sciences
0302 clinical medicine
Rheumatology
Musculoskeletal Pain
Internal medicine
medicine
Immunology and Allergy
Humans
030212 general & internal medicine
Longitudinal Studies
Obesity
Abdominal obesity
Aged
030203 arthritis & rheumatology
business.industry
Chronic pain
Middle Aged
medicine.disease
carbohydrates (lipids)
Causality
Cross-Sectional Studies
Cohort
Disease Progression
Female
Self Report
medicine.symptom
Chronic Pain
Waist Circumference
business
Body mass index
Subjects
Details
- ISSN :
- 1437160X
- Volume :
- 40
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Rheumatology international
- Accession number :
- edsair.doi.dedup.....7f2c3a1256252bab133a1378def09394