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Self-assembly of collagen bundles and enhanced piezoelectricity induced by chemical crosslinking
- Source :
- Nanoscale
- Publication Year :
- 2019
- Publisher :
- Royal Society of Chemistry (RSC), 2019.
-
Abstract
- The piezoelectricity of collagen is purported to be linked to many biological processes including bone formation and wound healing. Although the piezoelectricity of tissue-derived collagen has been documented across the length scales, little work has been undertaken to characterise the local electromechanical properties of processed collagen, which is used as a base for tissue-engineering implants. In this work, three chemically distinct treatments used to form structurally and mechanically stable scaffolds— EDC-NHS, genipin and tissue transglutaminase—are investigated for their effect on collagen piezolectricity. Crosslinking with EDC-NHS is noted to produce a distinct self-assembly of the fibres into bundles roughly 300 nm in width regardless of the collagen origin. These fibre bundles also show a localised piezoelectric response, with enhanced vertical piezoelectricity of collagen. Such topographical features are not observed with the other two chemical treatments, although the shear piezoelectric response is significantly enhanced upon crosslinking. These observations are reconciled by a proposed effect of the crosslinking mechanisms on the molecular and nanostructure of collagen. These results highlight the ability to modify the electromechanical properties of collagen using chemical crosslinking methods.
- Subjects :
- Paper
Nanostructure
Succinimides
02 engineering and technology
Microscopy, Atomic Force
010402 general chemistry
01 natural sciences
chemistry.chemical_compound
Tissue engineering
GTP-Binding Proteins
Elastic Modulus
Iridoids
Protein Glutamine gamma Glutamyltransferase 2
General Materials Science
Bone formation
Elastic modulus
Transglutaminases
Tissue Engineering
Chemistry
021001 nanoscience & nanotechnology
Piezoelectricity
Nanostructures
3. Good health
0104 chemical sciences
Cross-Linking Reagents
Genipin
Biophysics
Collagen
Self-assembly
0210 nano-technology
Wound healing
Subjects
Details
- ISSN :
- 20403372 and 20403364
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Nanoscale
- Accession number :
- edsair.doi.dedup.....7f2a98a560c9aca6fff42350a79d9168