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The association between lung innate immunity and differential airway antigen- specific immune responses
- Source :
- International Immunology. 8:499-507
- Publication Year :
- 1996
- Publisher :
- Oxford University Press (OUP), 1996.
-
Abstract
- The mechanisms involved in the differential regulation of airway immune responses in atopic versus non-atopic individuals are poorly understood. In this study, the association between non-specific immunity and the differential airway antigen-specific immune responses was examined in a murine model. The disparity in antigen-specific IgE and IgG2a productions between the two strains of mice was observed to be significant. C57BL/6J mice were much more efficient than BALB/cJ mice in making IgE antibody to inhaled ovalbumin (OVA) antigen. On the contrary, BALB/cJ mice did make more IgG2a antibodies than C57BL/6J mice to inhaled OVA. These findings suggest that in C57BL/6J mouse strain a predominant Th2 type of immune response develops in response to inhaled OVA antigen. In contrast, BALB/cJ mice mount a Th1 type of immune response to aerosolized OVA antigen. Furthermore, after lipopolysaccharide (LPS) stimulation, the IL-12 mRNA expression of lung-derived cells from BALB/cJ mice was higher than that from C57BL/6J cells. However, the lung-derived cells of C57BL/6J mice stimulated by LPS produced higher levels of IL-10 and prostaglandin E2 than BALB/cJ lung-derived cells did. Therefore, our study demonstrated that the difference of lung-derived cells in their ability to produce cytokine and prostaglandin between BALB/cJ and C57BL/6J mice correlates well with the type of the airway antigen-specific immune effector functions.
- Subjects :
- CD4-Positive T-Lymphocytes
Hypersensitivity, Immediate
Lipopolysaccharides
Male
Lipopolysaccharide
medicine.medical_treatment
Immunology
Bronchi
Immunoglobulin E
Dinoprostone
Mice
chemistry.chemical_compound
Th2 Cells
Immune system
Antigen
T-Lymphocyte Subsets
medicine
Animals
Immunology and Allergy
Lung
Ovum
Mice, Inbred BALB C
Innate immune system
Base Sequence
biology
General Medicine
Th1 Cells
respiratory system
Interleukin-12
Immunity, Innate
Interleukin-10
Mice, Inbred C57BL
Cytokine
chemistry
Immunoglobulin G
biology.protein
Interleukin 12
Female
Antibody
Subjects
Details
- ISSN :
- 14602377 and 09538178
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- International Immunology
- Accession number :
- edsair.doi.dedup.....7f2234a413992ae2f543c2f1dae0d009
- Full Text :
- https://doi.org/10.1093/intimm/8.4.499