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The association between lung innate immunity and differential airway antigen- specific immune responses

Authors :
Jong-Yih Lin
Li-Fang Wang
Rong-Hwa Lin
Source :
International Immunology. 8:499-507
Publication Year :
1996
Publisher :
Oxford University Press (OUP), 1996.

Abstract

The mechanisms involved in the differential regulation of airway immune responses in atopic versus non-atopic individuals are poorly understood. In this study, the association between non-specific immunity and the differential airway antigen-specific immune responses was examined in a murine model. The disparity in antigen-specific IgE and IgG2a productions between the two strains of mice was observed to be significant. C57BL/6J mice were much more efficient than BALB/cJ mice in making IgE antibody to inhaled ovalbumin (OVA) antigen. On the contrary, BALB/cJ mice did make more IgG2a antibodies than C57BL/6J mice to inhaled OVA. These findings suggest that in C57BL/6J mouse strain a predominant Th2 type of immune response develops in response to inhaled OVA antigen. In contrast, BALB/cJ mice mount a Th1 type of immune response to aerosolized OVA antigen. Furthermore, after lipopolysaccharide (LPS) stimulation, the IL-12 mRNA expression of lung-derived cells from BALB/cJ mice was higher than that from C57BL/6J cells. However, the lung-derived cells of C57BL/6J mice stimulated by LPS produced higher levels of IL-10 and prostaglandin E2 than BALB/cJ lung-derived cells did. Therefore, our study demonstrated that the difference of lung-derived cells in their ability to produce cytokine and prostaglandin between BALB/cJ and C57BL/6J mice correlates well with the type of the airway antigen-specific immune effector functions.

Details

ISSN :
14602377 and 09538178
Volume :
8
Database :
OpenAIRE
Journal :
International Immunology
Accession number :
edsair.doi.dedup.....7f2234a413992ae2f543c2f1dae0d009
Full Text :
https://doi.org/10.1093/intimm/8.4.499