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Detection and molecular epidemiology of canine parvovirus type 2 (CPV-2) circulating in Jilin Province, Northeast China
- Source :
- Comparative immunology, microbiology and infectious diseases. 74
- Publication Year :
- 2020
-
Abstract
- Canine parvovirus (CPV) is highly contagious and can cause haemorrhagic enteritis and myocarditis in dogs. To understand the current epidemic situation of CPV in Jilin Province, China, a total of 44 fecal or intestinal tissue samples of pet dogs suspected of being infected with CPV from February 2018 to November 2019 in Changchun and Liaoyuan City, Jilin Province were collected.All of the 44 collected samples were tested positive to CPV-2 by a PCR assay. The sequencing and analyzing of complete VP2 genes showed that CPV-2c was the most prevalent variant (n = 31;70.4 %), followed by new-CPV-2a (n = 8;18.2 %), new-CPV-2b (n = 4; 9.1 %) and CPV-2 (n = 1; 2.3 %). Phylogenetic analysis revealed that the 31 CPV-2c strains in our study are closely related to local CPV-2c isolates in cluster I. The VP2 protein of the acquired CPV 2c strains all possessed the substitutions Ala5Gly, Phe267Tyr, Tyr324Ile, and Gln370Arg only one with a novel Arg481Lys mutation. These findings demonstrate that CPV-2c was the most prominent type of CPV circulating in Jilin in 2018–2019, clustered in a separate group that is far from the vaccine strains and suggest that further and extensive epidemiological investigation among pet dogs are warranted to provide information for usage and research of current vaccines.
- Subjects :
- medicine.medical_specialty
China
Myocarditis
Parvovirus, Canine
040301 veterinary sciences
animal diseases
viruses
030231 tropical medicine
Immunology
Biology
Disease cluster
Microbiology
0403 veterinary science
Parvoviridae Infections
03 medical and health sciences
0302 clinical medicine
Dogs
Epidemiology
Genetic variation
medicine
Immunology and Allergy
Animals
Dog Diseases
Feces
Haemorrhagic enteritis
Phylogeny
Molecular Epidemiology
General Veterinary
Molecular epidemiology
Canine parvovirus
04 agricultural and veterinary sciences
General Medicine
medicine.disease
biology.organism_classification
Virology
Infectious Diseases
Subjects
Details
- ISSN :
- 18781667
- Volume :
- 74
- Database :
- OpenAIRE
- Journal :
- Comparative immunology, microbiology and infectious diseases
- Accession number :
- edsair.doi.dedup.....7f1368db911bccc37bcc396411cc1e29