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Physiological skin FDG uptake: A quantitative and regional distribution assessment using PET/MRI
- Source :
- PLoS ONE, PLoS ONE, Vol 16, Iss 3, p e0249304 (2021)
- Publication Year :
- 2021
- Publisher :
- Public Library of Science, 2021.
-
Abstract
- Purpose To retrospectively assess the repeatability of physiological F-18 labeled fluorodeoxyglucose (FDG) uptake in the skin on positron emission tomography/magnetic resonance imaging (PET/MRI) and explore its regional distribution and relationship with sex and age. Methods Out of 562 examinations with normal FDG distribution on whole-body PET/MRI, 74 repeated examinations were evaluated to assess the repeatability and regional distribution of physiological skin uptake. Furthermore, 224 examinations were evaluated to compare differences in the uptake due to sex and age. Skin segmentation on PET was performed as body-surface contouring on an MR-based attenuation correction map using an off-line reconstruction software. Bland–Altman plots were created for the repeatability assessment. Kruskal–Wallis test was performed to compare the maximum standardized uptake value (SUVmax) with regional distribution, age, and sex. Results The limits of agreement for the difference in SUVmean and SUVmax of the skin were less than 30%. The highest SUVmax was observed in the face (3.09±1.04), followed by the scalp (2.07±0.53). The SUVmax in the face of boys aged 0–9 years and 10–20 years (1.33±0.64 and 2.05±1.00, respectively) and girls aged 0–9 years (0.98±0.38) was significantly lower than that of men aged ≥20 years and girls aged ≥10 years (p Conclusion PET/MRI enabled the quantitative analysis of skin FDG uptake with repeatability. The degree of physiological FDG uptake in the skin was the highest in the face and varied between sexes. Although attention to differences in body habitus between age groups is needed, skin FDG uptake also depended on age.
- Subjects :
- Skin Physiology
Male
Diagnostic Radiology
Abdomen
Medicine and Health Sciences
Medicine
Tomography
Skin
Multidisciplinary
medicine.diagnostic_test
Radiology and Imaging
Repeatability
Middle Aged
Magnetic Resonance Imaging
medicine.anatomical_structure
In Vivo Imaging
Positron emission tomography
Female
Anatomy
Integumentary System
Preclinical imaging
medicine.drug
Research Article
Adult
Imaging Techniques
Science
Standardized uptake value
Neuroimaging
Research and Analysis Methods
Sebaceous Glands
Exocrine Glands
Diagnostic Medicine
Fluorodeoxyglucose F18
Humans
Aged
Fluorodeoxyglucose
Scalp
business.industry
Biology and Life Sciences
Magnetic resonance imaging
Biological Transport
Age Groups
Positron-Emission Tomography
People and Places
Population Groupings
business
Nuclear medicine
Correction for attenuation
Head
Positron Emission Tomography
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 16
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....7f0c80711e1f55b5ebeb8331f382a284