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Influenza Vaccine Effectiveness for Fully and Partially Vaccinated Children 6 Months to 8 Years Old During 2011-2012 and 2012-2013: The Importance of Two Priming Doses
- Source :
- The Pediatric infectious disease journal. 35(3)
- Publication Year :
- 2017
-
Abstract
- Background Few studies have examined the effectiveness of full versus partial vaccination with inactivated trivalent influenza vaccines (IIV3) as defined by the US CDC Advisory Committee on Immunization Practices. Methods Respiratory swabs were collected from outpatients aged 6 months to 8 years with acute cough for ≤7 days in clinics in 5 states during the 2011-2012 and 2012-2013 influenza seasons. Influenza was confirmed by real-time reverse transcription polymerase chain reaction assay. Receipt of current season IIV3 and up to 4 prior vaccinations was documented from medical records and immunization registries. Using a test-negative design, vaccine effectiveness (VE) was estimated adjusting for age, race/ethnicity, medical conditions, study site and month of enrollment. Results We did not observe higher VE for children fully versus partially vaccinated with IIV3, as defined by US Advisory Committee on Immunization Practice, although our sample of partially vaccinated children was relatively small. However, among children aged 2-8 years in both seasons and against A(H3N2) and B influenza illness separately, VE point estimates were consistently higher for children who had received 2 doses in the same prior season compared with those without (VE range of 58%-80% vs. 33%-44%, respectively). Across seasons, the odds of A(H3N2) illness despite IIV3 vaccination were 2.4-fold (95% confidence interval: 1.4-4.3) higher among children who had not received 2 doses in the same prior season. We also noted residual protection among unvaccinated children who were vaccinated the previous season (VE range = 36%-40% across outcomes). Conclusion Vaccination with IIV3 may provide preventive benefit in subsequent seasons, including possible residual protection if vaccination is missed. Two vaccine doses in the same season may be more effective than alternative priming strategies.
- Subjects :
- Microbiology (medical)
Male
Pediatrics
medicine.medical_specialty
Influenza vaccine
Acute cough
Advisory committee
medicine.disease_cause
History, 21st Century
Article
03 medical and health sciences
0302 clinical medicine
030225 pediatrics
Influenza, Human
Outcome Assessment, Health Care
Influenza A virus
Medicine
Humans
030212 general & internal medicine
Child
business.industry
Medical record
Vaccination
Infant
Confidence interval
United States
Infectious Diseases
Immunization
Influenza Vaccines
Child, Preschool
Pediatrics, Perinatology and Child Health
Female
Seasons
business
Subjects
Details
- ISSN :
- 15320987
- Volume :
- 35
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- The Pediatric infectious disease journal
- Accession number :
- edsair.doi.dedup.....7f005c3d64f2b0ad31251d9fce216202