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Association of elevated serum aminotransferase levels with chronic kidney disease measures: hispanic community health study/study of latinos
- Source :
- BMC Nephrology, BMC Nephrology, Vol 22, Iss 1, Pp 1-11 (2021)
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Background Previous studies have shown an association between non-alcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD), but it is unclear whether the association is independent of metabolic syndrome. Methods Data from 13,006 participants aged 18 to 74 years in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) without viral hepatitis, excessive alcohol consumption, or high transferrin saturation levels were analyzed. Suspected NAFLD was defined as presence of sex-specific elevations in serum aminotransferase levels (aspartate aminotransferase (AST) > 37 U/L or alanine aminotransferase (ALT) > 40 U/L for men and AST or ALT > 31 U/L for women). Logistic regression was used to examine cross-sectional associations of elevated serum aminotransferase levels with low estimated glomerular filtration rate (eGFR 2 based on cystatin C), and with high urinary albumin-to-creatinine ratio (UACR) (> 17 mg/g in men and > 25 mg/ g in women) in separate models adjusting for demographic characteristics and metabolic syndrome. Results Mean (SD) age was 41 (0.27) years, and 45 % were male. Elevated serum aminotransferase levels were noted in 18.8 % of the population and were associated with greater odds of high UACR (OR = 1.31; 95 % CI = 1.10, 1.56) after adjusting for demographic characteristics; this association became non-significant after adjustment for metabolic syndrome (OR = 1.11, 95 % CI = 0.92, 1.33). In contrast, elevated serum aminotransferase levels were not associated with low eGFR (odds ratio (OR) = 0.73; 95 % confidence interval (CI) = 0.45, 1.18) after adjusting for covariates. Conclusions In this sample of diverse U.S. Hispanic Latino adults, elevated serum aminotransferase levels were not independently associated with measures of CKD.
- Subjects :
- Adult
Male
medicine.medical_specialty
Hispanics/Latinos
Population
Renal function
Race/ethnicity
Cohort Studies
Non-alcoholic Fatty Liver Disease
Risk Factors
NAFLD
Chronic kidney disease
Internal medicine
Odds Ratio
medicine
Albuminuria
Humans
Aspartate Aminotransferases
Obesity
Renal Insufficiency, Chronic
education
Metabolic Syndrome
education.field_of_study
Transferrin saturation
business.industry
Research
Fatty liver
Alanine Transaminase
Hispanic or Latino
Odds ratio
medicine.disease
Diseases of the genitourinary system. Urology
Logistic Models
Nephrology
Creatinine
Female
RC870-923
Aminotransferase levels
Metabolic syndrome
business
Glomerular Filtration Rate
Kidney disease
Subjects
Details
- ISSN :
- 14712369
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- BMC Nephrology
- Accession number :
- edsair.doi.dedup.....7ee312ede19dc74adae1b9a2c1a6651f