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mSLA-based 3D printing of acrylated epoxidized soybean oil - nano-hydroxyapatite composites for bone repair
- Source :
- Materials scienceengineering. C, Materials for biological applications. 130
- Publication Year :
- 2021
-
Abstract
- Structural bone allografts are used to treat critically sized segmental bone defects (CSBDs) as such defects are too large to heal naturally. Development of biomaterials with competent mechanical properties that can also facilitate new bone formation is a major challenge for CSBD repair. 3D printed synthetic bone grafts are a possible alternative to structural allografts if engineered to provide appropriate structure with sufficient mechanical properties. In this work, we fabricated a set of novel nanocomposite biomaterials consisting of acrylated epoxidized soybean oil (AESO), polyethylene glycol diacrylate (PEGDA) and nanohydroxyapatite (nHA) by using masked stereolithography (mSLA)-based 3D printing. The nanocomposite inks possess suitable rheological properties and good printability to print complex, anatomically-precise, ‘by design’ grafts. The addition of nHA to the AESO/PEGDA resin improved the tensile strength and fracture toughness of the mSLA printed nanocomposites, presumably due to small-scale reinforcement. By adding 10 vol% nHA, tensile strength, modulus and fracture toughness (KIc) were increased to 30.8 ± 1.2 MPa (58% increase), 1984.4 ± 126.7 MPa (144% increase) and 0.6 ± 0.1 MPa·m1/2 (42% increase), respectively (relative to the pure resin). The nanocomposites did not demonstrate significant hydrolytic, enzymatic or oxidative degradation when incubated for 28 days, assuring chemical and mechanical stability at early stages of implantation. Apatite nucleated and covered the nanocomposite surfaces within 7 days of incubation in simulated body fluid. Good viability and proliferation of differentiated MC3T3-E1 osteoblasts were also observed on the nanocomposites. Taken all together, our nanocomposites demonstrate excellent bone-bioactivity and potential for bone defect repair.
- Subjects :
- Materials science
Stereolithography
Simulated body fluid
Bioengineering
02 engineering and technology
Bone healing
Polyethylene glycol
Apatite
Biomaterials
03 medical and health sciences
chemistry.chemical_compound
Fracture toughness
Ultimate tensile strength
Composite material
030304 developmental biology
0303 health sciences
Nanocomposite
021001 nanoscience & nanotechnology
Soybean Oil
Epoxidized soybean oil
Durapatite
chemistry
Mechanics of Materials
visual_art
Printing, Three-Dimensional
visual_art.visual_art_medium
0210 nano-technology
Subjects
Details
- ISSN :
- 18730191
- Volume :
- 130
- Database :
- OpenAIRE
- Journal :
- Materials scienceengineering. C, Materials for biological applications
- Accession number :
- edsair.doi.dedup.....7ed43858dcad0f01add3b60e342b6fe2