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Asymmetric transfer hydrogenation of imines catalyzed by a Noyori-type Ru(II) complex—a parametric study
- Source :
- Tetrahedron: Asymmetry, ICT FP7 Publications Database, OpenAIRE
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- We present, to the best of our knowledge, the first parametric study of the asymmetric transfer hydrogenation of imines catalyzed by a Noyori-type catalytic complex based on ruthenium. A model imine for this study was 1-methyl-3,4-dihydroisoquinoline, and a well-known complex RuCl(η 6 - p -cymene)((1 S ,2 S )- N - p -toluenesulfonyl-1,2-diphenylethylenediamine) was chosen as the model catalyst. The reactions were performed in the presence of a formic acid–triethylamine mixture as the source of hydrogen. The parameters examined include general parameters, for example, concentration, temperature, and substrate-to-catalyst molar ratio, as well as parameters specific to this particular reaction, such as the amount of the hydrogenation mixture used, the ratio of its components, or the inhibitive effect of carbon dioxide. During this study, several unexpected parameters worth further investigation have emerged.
- Subjects :
- Hydrogen
010405 organic chemistry
Catalytic complex
Organic Chemistry
Imine
chemistry.chemical_element
010402 general chemistry
Transfer hydrogenation
01 natural sciences
Medicinal chemistry
Catalysis
0104 chemical sciences
Ruthenium
Inorganic Chemistry
chemistry.chemical_compound
chemistry
Molar ratio
Organic chemistry
Physical and Theoretical Chemistry
Parametric statistics
Subjects
Details
- ISSN :
- 09574166
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Tetrahedron: Asymmetry
- Accession number :
- edsair.doi.dedup.....7ec4a82c87c02e6f864c6b69a6b1df1d