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Cohort Study Examining the Association Between Blood Pressure and Cardiovascular Events in Patients With Peripheral Artery Disease
- Source :
- Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
- Publication Year :
- 2019
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2019.
-
Abstract
- Background Hypertension is an important risk factor for cardiovascular events in patients with peripheral artery disease; however, optimal blood pressure targets for these patients are poorly defined. This study investigated the association between systolic blood pressure ( SBP ) and cardiovascular events in a prospectively recruited patient cohort with peripheral artery disease. Methods and Results A total of 2773 patients were included and were grouped according to SBP at recruitment (≤120 mm Hg, n=604; 121–140 mm Hg, n=1065; and >140 mm Hg, n=1104). Adjusted Cox proportional hazards analyses suggested that patients with SBP ≤120 mm Hg were at greater risk of having a major cardiovascular event (myocardial infarction, stroke, or cardiovascular death) than patients with SBP of 121–140 mm Hg (adjusted hazard ratio, 1.36; 95% CI, 1.08–1.72; P =0.009). Patients with SBP >140 mm Hg had an adjusted hazard ratio of 1.23 (95% CI, 1.00–1.51; P =0.051) of major cardiovascular events compared with patients with SBP of 121–140 mm Hg. These findings were similar in sensitivity analyses only including patients receiving antihypertensive medications or focused on patients with a minimum of 3 months of follow‐up. Conclusions This cohort study suggests that patients with peripheral artery disease and SBP ≤120 mm Hg are at increased risk of major cardiovascular events. The findings suggest caution in intensive SBP lowering in this patient group.
- Subjects :
- Male
medicine.medical_specialty
Time Factors
Blood Pressure
Coronary Disease
030204 cardiovascular system & hematology
peripheral artery disease
Vascular Medicine
Peripheral Arterial Disease
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
Clinical Studies
Prevalence
Humans
Medicine
Prospective Studies
030212 general & internal medicine
Myocardial infarction
Risk factor
Prospective cohort study
Stroke
Aged
Original Research
business.industry
Incidence
Hazard ratio
Angiography
Middle Aged
medicine.disease
stroke
Survival Rate
myocardial infarction
Blood pressure
Peripheral Vascular Disease
major adverse cardiac event
Hypertension
Cohort
Cardiology
Female
Queensland
Cardiology and Cardiovascular Medicine
business
Follow-Up Studies
Cohort study
Subjects
Details
- ISSN :
- 20479980
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Journal of the American Heart Association
- Accession number :
- edsair.doi.dedup.....7eae4085b12f86c10b52c333c0ae613e