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Model-Informed Precision Dosing at the Bedside: Scientific Challenges and Opportunities

Authors :
Ranvir Mangat
Adam Frymoyer
Rob ter Heine
Srijib Goswami
Lawrence J. Lesko
Ron J. Keizer
Source :
Cpt Pharmacometrics and Systems Pharmacology, 7, 785-787, Cpt Pharmacometrics and Systems Pharmacology, 7, 12, pp. 785-787, CPT: Pharmacometrics & Systems Pharmacology
Publication Year :
2018

Abstract

Contains fulltext : 200252.pdf (Publisher’s version ) (Open Access) The development of model-informed precision dosing (MIPD) tools, especially in the form of native or web-based applications to be used at the bedside, has garnered marked attention in recent years. Their potential clinical benefit can be large, but it should be ensured that such tools make optimal use of available clinical data and have adequate predictive ability. Unique scientific challenges specific to MIPD remain, which may require adaptation of commonly used diagnostics in pharmacometrics.

Details

ISSN :
21638306
Database :
OpenAIRE
Journal :
Cpt Pharmacometrics and Systems Pharmacology, 7, 785-787, Cpt Pharmacometrics and Systems Pharmacology, 7, 12, pp. 785-787, CPT: Pharmacometrics & Systems Pharmacology
Accession number :
edsair.doi.dedup.....7eacc0ea63ccb35dfce3b79d65d1c267