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The long and the short of it: the MDM4 tail so far
- Source :
- Journal of Molecular Cell Biology
- Publication Year :
- 2019
- Publisher :
- Oxford University Press, 2019.
-
Abstract
- The mouse double minute 4 (MDM4) is emerging from the shadow of its more famous relative MDM2 and is starting to steal the limelight, largely due to its therapeutic possibilities. MDM4 is a vital regulator of the tumor suppressor p53. It restricts p53 transcriptional activity and also, at least in development, facilitates MDM2’s E3 ligase activity toward p53. These functions of MDM4 are critical for normal cell function and a proper response to stress. Their importance for proper cell maintenance and proliferation identifies them as a risk for deregulation associated with the uncontrolled growth of cancer. MDM4 tails are vital for its function, where its N-terminus transactivation domain engages p53 and its C-terminus RING domain binds to MDM2. In this review, we highlight recently identified cellular functions of MDM4 and survey emerging therapies directed to correcting its dysregulation in disease.
- Subjects :
- 0301 basic medicine
p53
Cell Maintenance
MDMX
Regulator
Cell Cycle Proteins
law.invention
03 medical and health sciences
Transactivation
MDM4
0302 clinical medicine
Proto-Oncogene Proteins c-mdm2
MDM2
law
Neoplasms
Proto-Oncogene Proteins
Genetics
Animals
Humans
cancer
MDM4-FL
Molecular Biology
Invited Review
biology
Cell Biology
General Medicine
Ubiquitin ligase
030104 developmental biology
MDM4-S
030220 oncology & carcinogenesis
biology.protein
Mdm2
Suppressor
Tumor Suppressor Protein p53
Corrigendum
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 17594685 and 16742788
- Volume :
- 11
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of Molecular Cell Biology
- Accession number :
- edsair.doi.dedup.....7ea688d8e52bf65916ec91723a3e01e5