A mesoscopic approach to understanding the mechanisms underlying the ion permeation on the discrete-state diagram

In the [Perspectives][1] series in the June 2010 issue ([Bahar, 2010][2]; [Bucher and Rothlisberger, 2010][3]; [Dror et al., 2010][4]; [Roux, 2010][5]; [Silva and Rudy, 2010][6]), a broad range of permeation events from femtoseconds to minutes in time scale and sub-angstrom to millimeter in space