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Heritability of subcortical brain measures
- Source :
- Den Braber, A, Bohlken, M M, Brouwer, R M, van 't Ent, D, Kanai, R, Kahn, R S, de Geus, E J C, Hulshoff Pol, H E & Boomsma, D I 2013, ' Heritability of subcortical brain measures : A perspective for future genome-wide association studies ', NeuroImage, vol. 83, pp. 98-102 . https://doi.org/10.1016/j.neuroimage.2013.06.027, den Braber, A, Bohlken, M M, Brouwer, R M, van t Ent, D, Kanai, R, Kahn, R S, de Geus, E J C, Hulshoff Pol, H E & Boomsma, D I 2013, ' Heritability of subcortical brain measures: A perspective for future genome-wide association studies ', NeuroImage, vol. 83, pp. 98-102 . https://doi.org/10.1016/j.neuroimage.2013.06.027, NeuroImage, 83, 98-102. Academic Press Inc.
- Publication Year :
- 2013
-
Abstract
- Several large imaging-genetics consortia aim to identify genetic variants influencing subcortical brain volumes. We investigated the extent to which genetic variation accounts for the variation in subcortical volumes, including thalamus, amygdala, putamen, caudate nucleus, globus pallidus and nucleus accumbens and obtained the stability of these brain volumes over a five-year period. The heritability estimates for all subcortical regions were high, with the highest heritability estimates observed for the thalamus (80) and caudate nucleus (88) and lowest for the left nucleus accumbens (44). Five-year stability was substantial and higher for larger [e.g., thalamus (88), putamen (86), caudate nucleus (87)] compared to smaller [nucleus accumbens (45)] subcortical structures. These results provide additional evidence that subcortical structures are promising starting points for identifying genetic variants that influence brain structure. © 2013 Elsevier Inc.
- Subjects :
- Netherlands Twin Register (NTR)
Male
Aging
Endophenotypes
Cognitive Neuroscience
Thalamus
Caudate nucleus
Hippocampal formation
Nucleus accumbens
Sensitivity and Specificity
Amygdala
Sex Factors
medicine
Humans
Longitudinal Studies
Putamen
Brain
Genetic Variation
Reproducibility of Results
Organ Size
Heritability
medicine.anatomical_structure
Globus pallidus
Neurology
nervous system
Female
Psychology
Neuroscience
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- ISSN :
- 10538119
- Volume :
- 83
- Database :
- OpenAIRE
- Journal :
- NeuroImage
- Accession number :
- edsair.doi.dedup.....7e93c26e8552de267b10f385110caa00
- Full Text :
- https://doi.org/10.1016/j.neuroimage.2013.06.027