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Constriction of the mitochondrial inner compartment is a priming event for mitochondrial division
- Source :
- Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017), Nature Communications, NATURE COMMUNICATIONS(8)
- Publication Year :
- 2017
- Publisher :
- Nature Portfolio, 2017.
-
Abstract
- Mitochondrial division is critical for the maintenance and regulation of mitochondrial function, quality and distribution. This process is controlled by cytosolic actin-based constriction machinery and dynamin-related protein 1 (Drp1) on mitochondrial outer membrane (OMM). Although mitochondrial physiology, including oxidative phosphorylation, is also important for efficient mitochondrial division, morphological alterations of the mitochondrial inner-membrane (IMM) have not been clearly elucidated. Here we report spontaneous and repetitive constriction of mitochondrial inner compartment (CoMIC) associated with subsequent division in neurons. Although CoMIC is potentiated by inhibition of Drp1 and occurs at the potential division spots contacting the endoplasmic reticulum, it appears on IMM independently of OMM. Intra-mitochondrial influx of Ca2+ induces and potentiates CoMIC, and leads to K+-mediated mitochondrial bulging and depolarization. Synergistically, optic atrophy 1 (Opa1) also regulates CoMIC via controlling Mic60-mediated OMM–IMM tethering. Therefore, we propose that CoMIC is a priming event for efficient mitochondrial division.<br />The role of morphological alterations in the mitochondrial inner-membrane in regulating mitochondrial division are unknown. Here, the authors describe spontaneous and repetitive constriction of the mitochondrial inner compartment, and suggest this acts as a priming event for efficient mitochondrial division.
- Subjects :
- Dynamins
0301 basic medicine
Science
General Physics and Astronomy
Oxidative phosphorylation
Mitochondrion
Biology
Mitochondrial Dynamics
Mitochondrial apoptosis-induced channel
Article
General Biochemistry, Genetics and Molecular Biology
GTP Phosphohydrolases
Mitochondrial Proteins
Rats, Sprague-Dawley
03 medical and health sciences
0302 clinical medicine
medicine
Animals
Humans
Dynamin
Neurons
Multidisciplinary
Endoplasmic reticulum
General Chemistry
medicine.disease
Mitochondria
Rats
Cell biology
Cytosol
030104 developmental biology
Mitochondrial Membranes
Optic Atrophy 1
Calcium
ATP–ADP translocase
sense organs
Microtubule-Associated Proteins
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 8
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Nature Communications
- Accession number :
- edsair.doi.dedup.....7e8e2076879d85d2e344cff8b57933e4