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Passive limb movement augments ventilatory response to CO2 via sciatic inputs in anesthetized rats
- Source :
- Respiratory Physiology & Neurobiology. 167:174-180
- Publication Year :
- 2009
- Publisher :
- Elsevier BV, 2009.
-
Abstract
- Passive limb movement (PLM) in humans induces a phasic hyperpnea, but the underlying physiological mechanisms remain unclear. We asked whether PLM in anesthetized rats would produce a similar phasic hyperpnea associated with an augmented ventilatory (V(E)) response to CO(2) that is dependent on sciatic afferents. The animals underwent 5 min threshold PLM, 3 min hypercapnia (5% CO(2)), and their combination (CO(2) exposure at the end of 2nd min of 5-min PLM) before and after bilateral transection of the sciatic nerves. We found that a threshold PLM evoked a phasic hyperpnea, similar to that denoted in humans, and an augmented V(E) response to CO(2). Both responses were greatly diminished by sciatic nerve transection. Moreover, similar responses were also evoked by electrically stimulating the central end of the transected sciatic nerve. Our findings suggest an ability of the sciatic afferents to augment the V(E) response to CO(2) that likely contributes to the PLM-induced hyperpnea.
- Subjects :
- Male
Pulmonary and Respiratory Medicine
Physiology
Movement
medicine.medical_treatment
Hemodynamics
Hyperpnea
Article
Hypercapnia
Rats, Sprague-Dawley
Heart rate
medicine
Animals
Respiratory system
Muscle, Skeletal
business.industry
General Neuroscience
fungi
Motion Therapy, Continuous Passive
Axotomy
Extremities
Carbon Dioxide
Hypoxia (medical)
medicine.disease
Sciatic Nerve
Rats
nervous system
Anesthesia
Sciatic nerve
medicine.symptom
Pulmonary Ventilation
business
Subjects
Details
- ISSN :
- 15699048
- Volume :
- 167
- Database :
- OpenAIRE
- Journal :
- Respiratory Physiology & Neurobiology
- Accession number :
- edsair.doi.dedup.....7e7ba099397ed9dfad9b0bdc656d16d2