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Association of Maternal Hypothyroidism With Cardiovascular Diseases in the Offspring
- Source :
- Frontiers in Endocrinology, Frontiers in Endocrinology, Vol 12 (2021), Miao, M, Liu, H, Yuan, W, Madsen, N, Yu, Y, László, K D, Liang, H, Ji, H & Li, J 2021, ' Association of Maternal Hypothyroidism With Cardiovascular Diseases in the Offspring ', Frontiers in Endocrinology, vol. 12, 739629 . https://doi.org/10.3389/fendo.2021.739629
- Publication Year :
- 2021
- Publisher :
- Frontiers Media S.A., 2021.
-
Abstract
- BackgroundNo previous study has examined the effect of maternal hypothyroidism on a broad spectrum of cardiovascular disease (CVD) endpoints in the offspring.MethodsA nationwide population-based cohort study based on the linkage of several Danish nationwide registries was conducted to explore whether maternal hypothyroidism is associated with offspring’s CVD. Altogether 1,041,448 singletons born between the 1st of January 1978 and the 31st of December 1998 were investigated from the age of 8 years to the 31st of December 2016. Exposure was maternal diagnosis of hypothyroidism across lifespan and the outcome of interest was a CVD diagnosis in the offspring. Cox regression models were performed to estimate the hazard ratios (HRs) of CVD.ResultsOffspring born to mothers with hypothyroidism had an increased risk of CVD (hazard ratios (HR)=1.23, 95% confidence interval (CI): 1.12-1.35), and of several subcategories of CVD including hypertension, arrhythmia, and acute myocardial infarction in offspring. The magnitude of association was the most pronounced in an exposure occur during pregnancy (HR=1.71, 95% CI: 1.10-2.67), which is consistent across all the subgroup analysis, including sibling analysis.ConclusionsMaternal hypothyroidism is associated with an increased risk of CVD in offspring. Thyroid hormone insufficiency during pregnancy may predominantly contribute to the observed associations; however, the effects of a shared genetic background and a time-stable familial environment/lifestyle factors cannot be excluded.
- Subjects :
- Adult
medicine.medical_specialty
Adolescent
Offspring
Endocrinology, Diabetes and Metabolism
Denmark
Population
Diseases of the endocrine glands. Clinical endocrinology
Young Adult
Maternal hypothyroidism
Endocrinology
Hypothyroidism
cardiovascular disease
Pregnancy
medicine
Humans
register-based
Registries
education
Child
Original Research
education.field_of_study
Obstetrics
business.industry
Proportional hazards model
nationwide cohort study
Hazard ratio
medicine.disease
RC648-665
Confidence interval
in utero exposure
Pregnancy Complications
Cardiovascular Diseases
Prenatal Exposure Delayed Effects
Female
hypothyroidism
business
Cohort study
Subjects
Details
- Language :
- English
- ISSN :
- 16642392
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Frontiers in Endocrinology
- Accession number :
- edsair.doi.dedup.....7e76bdf35fb8f00d62aad589a6f81ec4