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Effect of allopurinol on phosphocreatine recovery and muscle function in older people with impaired physical function: a randomised controlled trial
- Source :
- Age and Ageing
- Publication Year :
- 2020
- Publisher :
- Oxford University Press (OUP), 2020.
-
Abstract
- Background Allopurinol has vascular antioxidant effects and participates in purinergic signalling within muscle. We tested whether allopurinol could improve skeletal muscle energetics and physical function in older people with impaired physical performance. Methods We conducted a randomised, double blind, parallel group, placebo-controlled trial, comparing 20 weeks of allopurinol 600 mg once daily versus placebo. We recruited community-dwelling participants aged 65 and over with baseline 6-min walk distance of Results In total, 124 participants were randomised, mean age 80 (SD 6) years. A total of 59 (48%) were female, baseline 6-min walk distance was 293 m (SD 80 m) and baseline SPPB was 8.5 (SD 2.0). Allopurinol did not significantly improve PCr recovery rate (treatment effect 0.10 units [95% CI, −0.07 to 0.27], P = 0.25). No significant changes were seen in endothelial function, quality of life, lean body mass or SPPB. Allopurinol improved 6-min walk distance (treatment effect 25 m [95% 4–46, P = 0.02]). This was more pronounced in those with high baseline oxidative stress and urate. Conclusion Allopurinol improved 6-min walk distance but not PCr recovery rate in older people with impaired physical function. Antioxidant strategies to improve muscle function for older people may need to be targeted at subgroups with high baseline oxidative stress.
- Subjects :
- Aging
medicine.medical_specialty
Randomization
Phosphocreatine
Allopurinol
Walking
030204 cardiovascular system & hematology
Placebo
law.invention
older people
AcademicSubjects/MED00280
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Randomized controlled trial
Quality of life
law
Internal medicine
medicine
Humans
oxidative stress
030212 general & internal medicine
skeletal muscle
Muscle, Skeletal
Aged
Aged, 80 and over
business.industry
Skeletal muscle
physical performance
General Medicine
medicine.anatomical_structure
chemistry
Quality of Life
Cardiology
Lean body mass
Female
Geriatrics and Gerontology
business
human activities
Research Paper
medicine.drug
Subjects
Details
- ISSN :
- 14682834 and 00020729
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- Age and Ageing
- Accession number :
- edsair.doi.dedup.....7e663f987b1fbf51c133da29805a128d